Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or...
Reexamination Certificate
2008-08-06
2010-10-26
Gitomer, Ralph (Department: 1657)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
C600S483000
Reexamination Certificate
active
07820373
ABSTRACT:
The present invention relates to a method for determining a risk whether an individual will suffer from a cardiovascular adverse event as a consequence of cardiac stress testing, comprising the steps of (a) measuring, preferably in vitro, the level of placenta growth factor, wherein (b) if the level of the placenta growth factor is at least increased, then the individual is at least at risk of suffering from an adverse event as a consequence of cardiac stress testing. In a further embodiment, additionally another marker is measured, particularly a natriuretic peptide, most particularly NT-proBNP. The present invention allows to stratify patients according to the environment and conditions under which cardiac stress testing should be carried out.
REFERENCES:
patent: 2004/0243010 (2004-12-01), Zoghbi et al.
patent: 2007/0042438 (2007-02-01), Zeiher et al.
patent: 2009/0081702 (2009-03-01), Hess et al.
Weber M. et al. N-Terminal B-Type Natriuretic Peptide Predicts Extent of Coronary Artery Disease . . . American Heart Journal 148:612-620, 2004.
Sabatine M. et al. Acute Changes in Circulating Natriuretic Peptide Levels in Relation to Myocardial Ischemia. J of the American College of Cardiology 44(10)1988-95, 2004.
Foote R. et al. Detection of Exercise Induced Ischemia by Changes in B-Type Natriuretic Peptides. J of the American College of Cardiology 44(10)1980-7, 2004.
Hess Georg
Horsch Andrea
Amick Marilyn L.
Gitomer Ralph
Roche Diagnostics Operations Inc.
Roche Diagnostics Operations Inc.
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