Natriuretic hormone

Details Natriuretic hormone Natriuretic hormone

1990-06-13

1992-04-21

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Extract, body fluid, or cellular material of undetermined...

424528, 424529, 424543, 424545, 514169, 514869, 514 63, 552505, A61K 3512, A61K 3514, A61K 3522, A01N 4500

Patent

active

051066300

ABSTRACT:
A purified naturally occurring natriuretic compound, identified as Natriuretic Hormone, and a method for isolation of the compound. The natriuretic compound has a molecular weight of about 360, a molecular formula of C.sub.21 H.sub.28 O.sub.5 and with a steroidal nucleus. The compound is useful as a diuretic in the treatment of diseases such as heart disease and hypertension.

REFERENCES:
patent: 4727061 (1988-02-01), Kramer et al.
patent: 4780314 (1988-10-01), Graves
Bourgoignie, J. et al., Inhibition of Transepithelial Sodium Transport in the Frog Skin by a Low Molecular Weight Fraction of Uremic Serum, J. of Clinical Investigation, 50:303-311 (1971).
Bourgoignie, J. et al., The Presence of a Natriuretic Factor in Urine of Patients with Chronic Uremia, J. of Clinical Investigation, 53:1559-1567 (1974).
Slatopolsky, E. et al., Studies on the Characteristics of the Control System Governing Sodium Excretion in Uremic Man, J. of Clinical Investigation, 47:521-530 (1968).
Kaloyanides, G. et al., Failure of Selected Endocrine Organ Ablation to Modify the Naturiuresis of Blood Volume Expansion in the Dog, Clin. Sci. and Mol. Medicine, 52:351-356 (1977).
de Bold, A. et al., A Rapid and Potent Natriuretic Response to Intravenous Injection of Atrial Myocardial Extract in Rats, Life Sciences, 28:89-94 (1981).
Haddy, F. and Overbeck H., The Role of Humoral Agents in Volume Expanded Hypertension, Life Sciences, 19:935-948 (1976).
Millett, Jr. et al., Na-K-ATPase-Inhibiting and Glucose-6-Phosphate Dehydrogenase-Stimulating Activity of Plasma and Hypothalamus of the Okamoto Spontaneously Hypertensive Rat, J. Endocr., 108:69-73 (1986).
Kramer, H., Natriuretic Hormone--A Circulating Inhibitor of Sodium-and Potassium-Activated Adenosine Triphosphatase, Klin Wochenschr, 59:1225-1230 (1981).
Kramer, H. et al., Studies on Ouabain-Like Endogenous Natriuretic Factors in Human Urine. Inhibition of Na-K-ATPase and .sub.3 H-Ouabain Binding, Klin Wochenschr 64:760-766 (1986).
Bricker, N. and Licht, A., Natriuretic Hormone: Biologic Effects and Progress in Identification and Isolation, Elsevier/North Holland Biomedical Press, 399-408 (1980).
Hamlyn, J. et al., A Circulating Inhibitor of (Na.sup.+ +K.sup.+) ATPase Associated with Essential Hypertension, Nature, 300:650-652 (1982).
Valdes, R. et al., Protein Binding of Endogenous Digoxin-Immunoactive Factors in Human Serum and Its Variation with Clinical Condition, J. of Clin. Endocrinology and Metabolism, 60:1135-1143 (1985).
Licht, A. et al., Progress in Isolation and Purification of an Inhibitor of Sodium Transport Obtained from Dog Urine, Kidney International, 21:339-344 (1982).
De Wardener, H. and Clarkson, E., Concept of Natriuretic Hormone, Physiological Reviews 65:658, 745-746 (1985).
Morgan, K. et al., Isolation of a Sodium Transport Inhibitory Factor, Inhibitin, from Cultured Leukemic Promyelocytes, J. Clin. Invest., 74:1132-1142 (1984).
Tamura, M. et al., Isolation and Characterization of a Specific Endogenous Na.sup.30, K.sup.30 -ATPase Inhibitor from Bovine Adrenal, Biochemistry 27:4244-4253 (1988).

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