Natriuretic and anti-hypertensive compounds

Details Natriuretic and anti-hypertensive compounds Natriuretic and anti-hypertensive compounds

1997-03-24

1998-12-08

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540491, C07D28110, A61K 3155

Patent

active

058469672

ABSTRACT:
A compound having the formula I ##STR1## in which R.sub.1, R.sub.2 independently are OH, OOC--R.sub.3 or O--R.sub.3, and

REFERENCES:
Yeung, P.K.F., et al. "Pharmacokinetics and Metabolism of Diltiazem in Healthy Males and Females Following a Signal Oral Dose" Eur. J. Drug Metab. Pharmacokinet., vol. 18 pp. 119-206 (1993), pp. 200 and 204 only.
Y. Sugawara, et al. "Metabolism of Diltiazem I. Structure of New Acidic and Basic Metabolities in Rat, Dog and Man" J. Pharmacobio-Dyn. 11, 211-223 (1988), p. 221 only.
Murata, K. et al. "Pharmacokinetics of Diltiazem and Its Metabolities in Dogs After Oral Adminstration" Pharmaceatuical Research 10, 1165-8 (1993), p. 1166 only.
Maurer, Arch. Toxicol. 64, 218(1990).
H. Inoue et al., "Synthesis of Halogen-Substituted 1,5-Benzothiazepine Derivaties and Their Vasodilating and Hypotensive Activities," J. Med. Chem., vol. 34, No. 2, pp. 675-687 (1991).

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