Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-05-28
2000-08-08
MacMillan, Keith D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514255, A61K 31495
Patent
active
061002801
ABSTRACT:
A narcotic antagonist comprising, as its active component, a compound represented by the following formula (1) or a physiologically acceptable salt thereof: wherein each of R.sup.1 and R.sup.2, which may be identical to or different from each other, represents a hydrogen atom or a halogen atom; R.sup.3 represents a hydrogen atom, an alkyl group, or an acyl group; R.sup.4 represents a hydrogen atom, an alkyl group, an acyl group, an alkylsulfonyl group, or a carboxyl group which may be esterified; Ar represents a phenyl group which may have 1 to 3 substituents selected from the group consisting of a halogen atom, an alkyl group, an alkoxyl group, a nitro group, an amino group, an alkylamino group, and a hydroxyl group or Ar represents a monocyclic aromatic heterocyclic ring having a nitrogen atom; m represents a number of 1 to 5 inclusive; and n represents a number of 0 to 5 inclusive. Also, a medicament for the prevention and treatment of narcotic dependence is provided. The medicament is effective in the prevention and treatment of narcosic dependence due to cocaine, etc.
REFERENCES:
Database WPI Week 9519, Derwent Publications Ltd., London, Great Britain; AN 95-144708, XP 002045048 (Abstract of JP 07069892A).
Database WPI Week 9519, Derwent Publications Ltd., Lond, Great Britain; AN 95-144707, XP 002045049 (Abstract of JP 07069891A).
Harada Mariko
Inazu Masato
Masuda Tomoko
MacMillan Keith D.
Pola Chemical Industries Inc.
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