Narcistatin prodrugs

Details Narcistatin prodrugs Narcistatin prodrugs

2003-12-09

2008-12-09

Shiao, Rei-Tsang (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

C546S023000, C546S065000

Reexamination Certificate

active

07462609

ABSTRACT:
The present invention provides prodrugs derived from the sparingly soluble anticancer isocarbostyril narciclasine, a component of various Narcissus species, said prodrugs having potential for use against animal and human cancers. Also disclosed is an efficient procedure for the synthetic conversion of narciclasine to several more soluble cyclic phosphate compounds, including “narcistatin”.

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