Narcistatin prodrugs

Details Narcistatin prodrugs Narcistatin prodrugs

2011-08-09

2011-08-09

Shiao, Rei-tsang (Department: 1628)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S065000

Reexamination Certificate

active

07994320

ABSTRACT:
The present invention provides prodrugs derived from the sparingly soluble anticancer isocarbostyril narciclasine, a component of variousNarcissusspecies, said prodrugs having potential for use against animal and human cancers. Also disclosed is an efficient procedure for the synthetic conversion of narciclasine to several more soluble cyclic phosphate compounds, including “narcistatin”.

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