Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-11-25
1998-12-01
Dentz, Bernard
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514253, 544362, 546122, A61K 31435, C07D47104
Patent
active
058439579
ABSTRACT:
Naphthyridine derivative of the formula: ##STR1## wherein Ring A is substituted or unsubstituted pyridine, X is --N(R.sup.2)--CO--(R.sup.2 is H, alkyl, substituted alkyl, etc.), Z is a direct bond, --NH--, C.sub.1 -C.sub.2 alkylene, or --CH.dbd.CH--, Y is alkyl, substituted alkyl, aromatic group or substituted aromatic group, etc., B is alkyl, substituted alkyl, aromatic group or substituted aromatic group, or an acid addition salt thereof, these compounds having acyl-CoA: cholesterol acyl transferase inhibitory activity, and being useful as an agent for prophylaxis or treatment of hyperlipidemia, atherosclerosis, and related diseases thereof.
REFERENCES:
patent: 3993656 (1976-11-01), Rooney et al.
H. Tawada et al., Chem. Pharm. Bull. 43(4) 616-625 (1995).
Ioriya Katsuhisa
Muraoka Masami
Ohashi Naohito
Yagi Hideki
Dentz Bernard
Sumitomo Pharmaceuticals Company Ltd.
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