Naphthyridine-3-carboxamido-benzylpenicillins and salts thereof

Details Naphthyridine-3-carboxamido-benzylpenicillins and salts thereof Naphthyridine-3-carboxamido-benzylpenicillins and salts thereof

1973-12-13

1976-05-04

Schwartz, Gerald A.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424271, C07D49944

Patent

active

039547337

ABSTRACT:
Novel penicillins of the formula: ##SPC1##
Wherein the ring A is a benzene ring or a 5 or 6-membered heteroaromatic ring containing one or two nitrogen atoms as the hetero atom, on which one or more of lower alkyl, lower alkoxy, lower alkylthio, lower haloalkyl, lower alkylenedioxy, halogen, hydroxyl, nitro, free or protected amino, lower alkylamino, di(lower)alkylamino and lower alkanoylamino may be present, Z is a nitrogen atom or a methylene group, X is an oxygen atom or a sulfur atom, Y is a hydrogen atom, a lower alkoxycarbonyl group or a lower alkanoyl group, R.sub.1 is a free or protected hydroxyl group and R.sub.2 and R.sub.3 are each a hydrogen atom or a halogen atom, and their non-toxic pharmaceutically acceptable salts, and their preparation.

REFERENCES:
patent: 3248387 (1966-04-01), Alburn et al.
patent: 3433784 (1969-03-01), Long et al.
patent: 3453264 (1969-07-01), Fosker et al.

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