Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing
Reexamination Certificate
2001-10-02
2002-06-18
Kumar, Shailendra (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Amino nitrogen containing
C514S522000, C514S621000, C558S415000
Reexamination Certificate
active
06407288
ABSTRACT:
FIELD OF INVENTION
The present invention relates generally to the field of antimicrobial agents. More particularly, the present invention provides novel naphthylsalicylanilides and a method for the use of these compounds as antimicrobial and antiinflammatory agents.
DISCUSSION OF RELATED ART
Several Salicylanilide compounds have been identified as potential antimicrobial agents. Previously, some of these agents have been shown to be effective against microorganisms associated with dental plaques.
U.S. Pat. No. 4,287,191 discloses 5-acylsalicylanilides which are said to be effective antiseptics against a wide range of microorganisms, especially bacteria and the microorganisms prevalent in dental plaque. However, these compounds were not found to be effective against antibiotic resistant bacteria such as
S. mutans
. The general structure of these compounds can be represented by the following formula:
Wherein Z is a substituted phenyl ring, R is a substituted or unsubstituted alkyl or phenyl group and X is —CN, —F, NO
2
, —H, lower alkyl or lower haloalkyl.
U.S. Pat. No. 4,358,443 discloses 5-alkylsalicylanilides having the same general formula as above wherein R is a substituted or unsubstituted -alkyl or phenyl group.
U.S. Pat. No. 4,939,132 discloses 5-sulfonylalkylsalicylanilides as antimicrobials having the same general formula as above wherein R is a substituted or unsubstituted alkylsulfonyl group.
U.S. Pat. Nos. 4,742,083 and 5,958,911 disclose antiinflammatory effects of salicylanilides.
Given the constant emergence of antibiotic resistant bacteria, there is an ongoing need for novel antimicrobial agents effective against a wide variety of bacteria.
SUMMARY OF THE INVENTION
The present invention provides novel aroylsalicylanilides. In particular, the present invention provides novel 5-naphthylsalicylanilides and describes the antimicrobial effects of these compounds against a wide variety of bacteria. Further, this invention also provides a method of using these compounds for obtaining relief from infections associated with the bacteria.
Accordingly, it is an object of the invention to provide novel naphthylsalicylanilides
Another object of the present invention is to provide a method for the use of naphthylsalicylanilides as antimicrobial agents.
A yet another object of the present invention is to provide a method for the control of periodontal disease.
REFERENCES:
patent: 4287191 (1981-09-01), Coburn et al.
patent: 4358443 (1982-11-01), Coburn et al.
patent: 4742083 (1988-05-01), Ritchey
patent: 4939132 (1990-07-01), Coburn et al.
patent: 5958911 (1999-09-01), Evans et al.
Coburn Robert A.
Evans Richard T.
Genco Robert J.
Hodgson & Russ LLP
Kumar Shailendra
The Research Foundation of State University of New York
LandOfFree
Naphthylsalicylanilides as antimicrobial and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Naphthylsalicylanilides as antimicrobial and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Naphthylsalicylanilides as antimicrobial and... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2892116