Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters
Patent
1983-03-03
1984-06-12
Killos, Paul J.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acid esters
560 56, 562467, 562490, 564172, 564180, 424308, 424317, 424324, C07C 6976
Patent
active
044543417
ABSTRACT:
Compounds of the formulas: ##STR1## where X is methyl, methoxy, chlorine, or hydrogen, Y and Y.sub.1 are fluorine or hydrogen, R is hydroxy, alkoxy with 0 or 1 hydroxy substituent, aroxy, or NR.sup.1 R.sup.2 where R.sup.1 is hydrogen, alkyl with 0 or 1 hydroxy substituent or aryl and R.sup.2 is alkyl with 0 or 1 hydroxy substituent or aryl with the proviso that when Y or Y.sup.1 is fluorine, the other Y or Y.sup.1 is hydrogen. These compounds are useful as chemopreventive agents for inhibiting tumor promotion in epithelial cells and for treating nonmalignant skin disorders.
REFERENCES:
patent: 3821253 (1974-06-01), Fried et al.
patent: 3896157 (1975-07-01), Fried et al.
patent: 4326055 (1982-04-01), Lolliger
patent: 4356188 (1982-10-01), Pacheco et al.
Boutwell, R. K. et al., Adv. in Enzyme Regulation, vol. 17, Ed. Weber, G. Pergamon Press (1979).
Verma, A. K. et al., Cancer Res. (1979) 39: 419-427.
Verma and Boutwell, Cancer Res. (1979) 37: 2196-2201.
Loeliger, P. et al., Eur. J. Med. Chem.-Chemia Therapeutica (1980) 15: 9-15.
Dawson Marcia I.
Derdzinski Krzysztof A.
Hobbs Peter D.
Killos Paul J.
SRI - International
LandOfFree
Naphthyl or tetrahydronaphthyl-substituted naphthoic acid and de does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Naphthyl or tetrahydronaphthyl-substituted naphthoic acid and de, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Naphthyl or tetrahydronaphthyl-substituted naphthoic acid and de will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-122758