Naphthyl ketone inhibitors of cholesterol esterase and their use

Details Naphthyl ketone inhibitors of cholesterol esterase and their use Naphthyl ketone inhibitors of cholesterol esterase and their use

1990-07-02

1992-03-03

Reamer, James H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ketone doai

568328, A61K 3112

Patent

active

050933710

ABSTRACT:
Certain 2-naphthyl ketones are used as inhibitors of cholesterol esterase and function as hypolipidemic and hypocaloric agents. The invention also relates to a method of decreasing the absorption of dietary cholesterol and fats through the wall of the intestinal tract.

REFERENCES:
patent: 3641161 (1972-02-01), Fried et al.
patent: 4288453 (1981-09-01), Vincent et al.
patent: 4803013 (1989-02-01), Yokoyama
Sohl, Julie, et al., "Haloketone Transition State Analog Inhibitors of Cholesterol Esterase", Bioch. & Biophy. Res. Comm, vol. 151, No. 1, Feb. 29, 1988, pp. 554-560.

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