Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1997-03-27
2000-09-19
Ambrose, Michael G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514319, 546205, 564157, A61K 31165, C07C23722
Patent
active
06121325&
ABSTRACT:
The present invention is directed to certain compounds of the general structural formula: ##STR1## wherein R.sub.1, R.sub.1a, R.sub.2a, R.sub.3, R.sub.3a, R.sub.4, R.sub.5, R.sub.6, A, W, and n are as defined herein. These compounds promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to treat physiological or medical conditions characterized by a deficiency in growth hormone secretion, such as short stature in growth hormone deficient children, and to treat medical conditions which are improved by the anabolic effects of growth hormone. Growth hormone releasing compositions containing such compounds as the active ingredient thereof are also disclosed.
REFERENCES:
patent: 4411890 (1983-10-01), Momany
patent: 4522824 (1985-06-01), Wagnon et al.
patent: 4658038 (1987-04-01), Tamir et al.
patent: 5324737 (1994-06-01), D'Ambra et al.
patent: 5798337 (1998-08-01), Somers et al.
Smith, et al., Science, "A Nonpeptidyl Growth Hormone Secretagogue", vol. 260, pp. 1640-1643, Jun. 11, 1993.
Slide of Presentation on "Genentech Growth Hormone Secretagogues" by Todd Somers, at Serano Symposium on Growth Hormone Secretagogues, in St. Petersburg, Florida, Dec. 5-8, 1994.
McDowell, et al., Proc. Natl. Acad. Sci. USA, 92, 11165-11169 (Nov. 1995) "Growth hormone secretagogues: Characterization, efficacy, and minimal bioactive conformation".
Chen Meng Hsin
Morriello Gregori J.
Nargund Ravi
Patchett Arthur A.
Yang Lihu
Ambrose Michael G.
Merck & Co. , Inc.
Rose David L.
Thies J. Eric
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