Naphthyl and tetrahydronaphthyl di-ethers

Details Naphthyl and tetrahydronaphthyl di-ethers Naphthyl and tetrahydronaphthyl di-ethers

1974-04-10

1976-12-07

Hines, Robert V.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260348R, 26050118, 260612D, 260621N, 260623R, 260626R, 424316, 424330, C07C 9306

Patent

active

039962849

ABSTRACT:
Naphthyl and tetrahydronaphthyl diethers of the formula ##STR1## wherein A represents a naphthylene group or a 5,6,7,8-tetrahydronaphthylene group having their ether chains attached to the 1 and 2 or 2 and 3 positions or, when A represents a naphthylene group, to the 1 and 8 positions, which aromatic groups may also have substituted therein one to three substituents selected from halogen atoms, lower alkyl, lower alkenyl, benzyl, nitro and lower acyl groups, said substituents being present in the aromatic part in case A represents a 5,6,7,8-tetrahydronaphthylene group and R represents an isopropyl or tertiary butyl group, and acid addition salts thereof.
The compounds are useful anti-arrhythmic agents and also show local anaesthetic activity in mammals.

REFERENCES:
patent: 3033640 (1962-05-01), Hofer et al.
patent: 3337628 (1967-08-01), Crowther et al.
patent: 3432545 (1969-03-01), Horne
Kranz et al., "Chemical Abstracts", vol. 67, p. 6011, Section 64046k (1967).
Terentev et al., "Chemical Abstracts", vol. 57, pp. 16455-16456 (1962).

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