Naphtho thiazine (or oxaline) derivatives and preparations there

Details Naphtho thiazine (or oxaline) derivatives and preparations there Naphtho thiazine (or oxaline) derivatives and preparations there

1991-01-31

1993-09-21

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

5142298, 544 32, 544 73, 544101, A61K 3154, C07D27922, C07D26538

Patent

active

052469298

ABSTRACT:
Thiazine (or oxazine) derivatives of the formula [I]: ##STR1## wherein R.sup.1 and R.sup.2 are both H or form a naphthalene ring together with the benzene ring; R.sup.3 and R.sup.4 are both H, or one of them is halogen and another is H; X is S or O; R.sup.5 and R.sup.6 are each i) H, ii) lower alkyl, iii) cycloalkyl, iv) substituted phenyl, v) naphthyl, vi) lower alkyl which is substituted by substituted or unsubstituted phenyl, or vii) S-containing heterocyclic group; one of Z.sup.1 and Z.sup.2 is O and another is H.sub.2 ; A is lower alkylene; R.sup.7 and R.sup.8 are each i) H, ii) lower alkyl, iii) lower alkenyl, iv) lower alkynyl, or v) lower alkyl which is substituted by substituted or unsubstituted phenyl, or both form together N-containing heterocyclic group; provided that when both of R.sup.1 and R.sup.2 are H, Z.sup.2 is O and either one of R.sup.5 and R.sup.6 is substituted phenyl, naphthyl or S-containing heterocyclic group, or their salts, which have calcium antagonistic activity within the cerebral tissues and are useful for prophylaxis and treatment of ischemic encephalopathia and/or cerebral neurocyte dyscrasia, and process for preparing said compounds.

REFERENCES:
patent: 3143545 (1964-04-01), Lowrie et al.
patent: 3395150 (1968-07-01), Krapcho
patent: 3547915 (1970-12-01), Bub
patent: 3681330 (1972-08-01), Pesson
patent: 3705894 (1972-12-01), Gerzon et al.
patent: 3748321 (1973-07-01), Krapcho
patent: 3879522 (1975-04-01), Pesson
patent: 4107167 (1978-08-01), Lorenz et al.
patent: 4534300 (1986-04-01), Iwao et al.
Iwao et al.; "Chemical Abstract", vol. 104(13), 1985, #109666P.
Iwao et al., "Chemical Abstract", vol. 102(3) 1984, #24637P.
Abstract of Japan 60-166674 (A), vol. 10, No. 13(C-323) (2070), Jan. 1986.
G. R. Clemo et al., Journal of the Chemical Society Transactions; vol. 121, pp. 642-649, (1922).

Affiliated with

Also associated with

Rating

Naphtho thiazine (or oxaline) derivatives and preparations there does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Naphtho thiazine (or oxaline) derivatives and preparations there, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Naphtho thiazine (or oxaline) derivatives and preparations there will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1049914