Naphthenic and heterocyclic retinoic acid analogues

Details Naphthenic and heterocyclic retinoic acid analogues Naphthenic and heterocyclic retinoic acid analogues

1982-10-15

1984-06-26

Raymond, Richard

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

424275, 424285, 424317, 424324, 424331, 424339, 542429, 549 57, 549 71, 549 72, 549467, 549468, 549484, 549487, 560 56, 560100, 562467, 562490, 564180, 568440, 568441, 568592, A61K 31075, A61K 3111, A61K 31165, A61K 3119

Patent

active

044566182

ABSTRACT:
Naphthenic and heterocyclic retinoic acid analogues such as (E)-6-[2-(2,6,6-trimethyl-1-cyclohexen-1-yl)ethenyl]-2-naphthaldehyde, methyl 6-[2-(2,6,6-trimethyl-1-cyclohexen-1-yl)ethenyl]-2-naphthoate, 6-[2-(2,6,6-trimethyl-1-cyclohexen-1-yl)ethenyl]-2-naphthoic acid, (E)-1-(5-carbethoxy-2-furanyl)-2-methyl-4-(2,6,6-trimethyl-1-cyclohexen-1- yl)-1,3-butadiene, (E)-1-(5-carboxy-2-furanyl)-2-methyl-4-(2,6,6-trimethyl-1-cyclohexen-1-yl) -1,3-butadiene, (E)-1-(5-carbethoxythien-2-yl)-2-methyl-4-(2,6,6-trimethyl-1-cyclohexen-1- yl)-1,3-butadiene, and (E)-1-(5-carboxythien-2-yl)-2-methyl-4-(2,6,6-trimethyl-1-cyclohexen-1-yl) -1,3-butadiene. These retinoids are useful as chemopreventive agents for inhibiting tumor promotion in epithelial cells and for treating nonmalignant skin disorders.

REFERENCES:
Boutwell et al., Advances in Enzyme Regulation, vol. 17 (1979), pp. 89-112.
Verma et al., Cancer Res., vol. 39 (1979), pp. 419-427.
Dawson et al., J. Med. Chem., vol. 23 (1980), pp. 1013-1022.
Dawson et al., J. Med. Chem., vol. 24 (1981), pp. 583-592.

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