Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-06-07
2005-06-07
O'Sullivan, Peter G (Department: 1621)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S237500, C514S255010, C514S334000, C514S407000, C514S552000, C514S616000, C544S059000, C544S163000, C544S169000, C544S388000, C544S390000, C548S262800, C548S375100, C558S415000, C564S155000, C564S158000
Reexamination Certificate
active
06903092
ABSTRACT:
Compounds having the general formulawherein R1, R2, R3, R4, R5, X1and X2are as defined in the specification, methods of using such compounds for the treatment of diseases and pharmaceutical composition comprising such compounds.
REFERENCES:
patent: 5789422 (1998-08-01), Reichard et al.
patent: 5998439 (1999-12-01), Maynard et al.
patent: WO 9628158 (1996-09-01), None
patent: WO 0002859 (2000-01-01), None
patent: WO 0020003 (2000-04-01), None
patent: WO 0020389 (2000-04-01), None
patent: WO 0034243 (2000-06-01), None
patent: WO 0064423 (2000-11-01), None
Clin. Exp. Allergy, vol. 29, No. 2, 1999, Schuiling, M. et al., “Role of tachykinin NK1 and NK2 receptors in allergen-induced early and late asthmatic reactions, airway hyperresponsiveness, and airway inflammation in conscious, unrestrained guinea pigs”, p. 48-52. (The compounds SR 48968 and SR 140333 taken together.).
Eur. J. Pharmacol., vol. 361, No. 2/3, 1998, Coudore-Civiale, Marie-Ange et al., “Effect of tachykinin receptor antagonists in experimental neuropathic pain”, p. 175-184. (The compounds SR 48968 and SR 140333 taken together.).
Life Sci., vol. 63, No. 4, 1998, Mazelin, Ludmilla et al., “Comparative effects of nonpeptide tachykinin receptor antagonists on experimental gut inflammation in rats and guinea-pigs”, p. 293-304, (the compounds SR 48968 and SR 140333 taken together).
Eur. J. Pharmacol., vol. 415, No. 1, 2002, Giuliani, S. et al., “Effect of a tachykinin NK2 receptor antagonist, nepadutant, on cardiovascular and gastrointestinal function in rats and dogs”, p. 61-71, Abstract (states antihypertensive effects of SR 48968).
Cochran Karen
Mitchell Kenneth F.
O'Sullivan Peter G
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