Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...
Patent
1982-09-21
1984-05-01
Gerstl, Robert
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Parasitic organism or component thereof or substance...
548182, 548186, C07D27734, A61K 31425
Patent
active
044461500
ABSTRACT:
Disclosed herein are new aldose reductase inhibitors of the formula ##STR1## wherein R is ##STR2## wherein R.sup.1 is lower alkyl; R.sup.2 is halo and R.sup.3 is hydrogen, or R.sup.2 and R.sup.3 each is a substituent at positions 3, 4, 5 or 6 of the naphthalene ring selected from the group consisting of lower alkoxy, trihalomethyl, and halo; and R.sup.4 is lower alkyl. The derivatives are useful for treating or preventing diabetic complications.
REFERENCES:
patent: 2441558 (1948-05-01), Brooker
patent: 2474426 (1949-06-01), Kendall et al.
patent: 3539585 (1970-11-01), Sulkowski et al.
Bellini Francesco
Sestanj Kazimir
Ayerst McKenna & Harrison, Inc.
Gerstl Robert
Wilfond Arthur E.
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