Naphthalenylmethyl cycloalkenone acetic acids and analogs thereo

Details Naphthalenylmethyl cycloalkenone acetic acids and analogs thereo Naphthalenylmethyl cycloalkenone acetic acids and analogs thereo

1994-12-20

1996-01-09

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

N-c doai

514569, 514478, A61K 3127, A61K 3119

Patent

active

054829682

ABSTRACT:
The compounds of this invention which have the formula: ##STR1## wherein: R.sup.1 and R.sup.2 are independently hydrogen, C.sub.1 -C.sub.8 alkyl, halogen, C.sub.1 -C.sub.8 alkoxy, or trifluoromethyl;
R.sup.3 is --OH or --NHCO.sub.2 CH.sub.3 ;
X is --CH.sub.2 -- or --OCH.sub.2 --;
n is 1 or 2;
or a pharmaceutically acceptable salt thereof,
are useful in treating or inhibiting the long-term complications of diabetes such as diabetic retinopathy, nephropathy and neuropathy through the inhibition of the enzyme aldose reductase. Aldose reductase inhibitors have been shown to prevent the biochemical, functional and morphological changes induced by hyperglycemia.

REFERENCES:
patent: 4897405 (1990-01-01), Alessi
patent: 5183825 (1993-02-01), Kees
Beilstein 2626759, 1964.

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