Cleaning compositions for solid surfaces – auxiliary compositions – Cleaning compositions or processes of preparing – Enzyme component of specific activity or source
Patent
1996-10-21
1998-11-10
Fries, Kery A.
Cleaning compositions for solid surfaces, auxiliary compositions
Cleaning compositions or processes of preparing
Enzyme component of specific activity or source
510393, 510530, 510226, 510466, 510221, 510321, 510337, C11D 3386, C11D 302
Patent
active
058344152
DESCRIPTION:
BRIEF SUMMARY
CROSS-REFERENCE TO RELATED APPLICATIONS
This application is a 35 U.S.C. 371 national application of PCT/DK95/00168 filed Apr. 25, 1995, which is incorporated herein by reference.
FIELD OF INVENTION
This invention relates to a liquid detergent composition comprising a surfactant, an enzyme and an improved enzyme stabilizer.
BACKGROUND OF THE INVENTION
Storage stability problems are well known with liquids containing enzyme(s). Especially in enzyme-containing liquid detergents a major problem, in particular if the detergent contains protease, is that of ensuring enzyme activity over time.
The prior art has dealt extensively with improving the storage stability, for example by adding a protease inhibitor.
Boric acid and boronic acids are known to reversibly inhibit proteolytic enzymes. A discussion of the inhibition of one serine protease, subtilisin, by boronic acid is provided in Molecular & Cellular Biochemistry 51, 1983, pp. 5-32.
Boronic acids have very different capacities as subtilisin inhibitors. Boronic acids containing only alkyl groups such as methyl, butyl or 2-cyclohexylethyl are poor inhibitors with methylboronic acid as the poorest inhibitor, whereas boronic acids bearing aromatic groups such as phenyl, 4-methoxyphenyl or 3,5-dichlorophenyl are very good inhibitors with 3,5-dichlorophenylboronic acid as a particularly effective one (see Keller et al, Biochem. Biophys. Res. Com. 176, 1991, pp. 401-405).
It is also claimed that aryl boronic acids which have a substitution at the 3-position relative to boron are unexpectedly good reversible protease inhibitors. Especially, acetamidobenzene boronic acid is claimed to be a superior inhibitor of proteolytic enzymes (see WO 92/19707).
The inhibition constant (K.sub.i) is ordinarily used as a measure of capacity to inhibit enzyme activity, with a low K.sub.i indicating a more potent inhibitor. However, it has earlier been found that the K.sub.i values of boronic acids do not always tell how effective inhibitors are (see for instance WO 92/197077).
SUMMARY OF THE INVENTION
In this invention it is surprisingly found that naphthalene boronic acid derivatives have extraordinary good capacities as enzyme stabilizers in liquid detergents.
Accordingly, the present invention relates to a liquid detergent composition comprising a surfactant, an enzyme and a naphthalene boronic acid derivative enzyme stabilizer of the following formula: ##STR1## where R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6 and R.sub.7 is the same or different and selected from hydrogen, C.sub.1 -C.sub.6 alkyl, substituted C.sub.1 -C.sub.6 alkyl, aryl, substituted aryl, hydroxy, hydroxyl derivative, halogen, amine, alkylated amine, amine derivative, nitro, thiol, thiol derivative, aldehyde, acid, acid salt, ester, sulfonate or phosphonate.
DETAILED DISCLOSURE OF THE INVENTION
One embodiment of the present invention provides a liquid detergent composition comprising a surfactant, an enzyme and a naphthalene boronic acid derivative enzyme stabilizer of the following formula: ##STR2## where R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6 and R.sub.7 is the same or different and selected from hydrogen, C.sub.1 -C.sub.6 alkyl, substituted C.sub.1 -C.sub.6 alkyl, aryl, substituted aryl, hydroxy, hydroxyl derivative, halogen, amine, alkylated amine, amine derivative, nitro, thiol, thiol derivative, aldehyde, acid, acid salt, ester, sulfonate or phosphonate.
A preferred embodiment of the present invention provides a liquid detergent composition comprising a surfactant, an enzyme and a naphthalene boronic acid derivative enzyme stabilizer of the formula disclosed above, wherein at least five of the seven groups (R.sub.1 -R.sub.7) are hydrogen. Preferred examples belonging to this group are dihalogennaphthalene boronic acids such as dichloronaphthalene boronic acids.
A further preferred embodiment of the present invention provides a liquid detergent composition comprising a surfactant, an enzyme and a naphthalene boronic acid derivative enzyme stabilizer of the formula discl
REFERENCES:
patent: 5354491 (1994-10-01), Bjorkquist et al.
patent: 5422030 (1995-06-01), Panandiker et al.
patent: 5431842 (1995-07-01), Panandiker et al.
patent: 5472628 (1995-12-01), Panandiker et al.
patent: 5488157 (1996-01-01), Bjorkquist et al.
Deane-Wray Allison
Nielsen Lone Kierstein
Fries Kery A.
Lombiris Elias J.
Novo Nordisk A S
Zelson Steve T.
LandOfFree
Naphthalene boronic acids does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Naphthalene boronic acids, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Naphthalene boronic acids will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1516675