Naphthalene-based inhibitors of anti-apoptotic proteins

Details Naphthalene-based inhibitors of anti-apoptotic proteins Naphthalene-based inhibitors of anti-apoptotic proteins

2010-04-14

2011-10-18

Kumar, Shailendra (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C568S328000, C568S441000, C568S729000, C562S467000, C514S367000, C514S616000, C514S700000

Reexamination Certificate

active

08039668

ABSTRACT:
Methods of using apogossypol and its derivatives for treating inflammation is disclosed. Also, there is described a group of compounds having structure A, or a pharmaceutically acceptable salt, hydrate, N-oxide, or solvate thereof are provided:wherein each R is independently H, C(O)X, C(O)NHX, NH(CO)X, SO2NHX, or NHSO2X, wherein X is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, alkylaryl, substituted alkylaryl, heterocycle, or substituted heterocycle. Compounds of group A may be used for treating various diseases or disorders, such as cancer.

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