Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,... – Conjugated via claimed linking group – bond – chelating agent,...
Patent
1976-01-27
1981-08-18
Brown, Johnnie R.
Drug, bio-affecting and body treating compositions
Conjugate or complex of monoclonal or polyclonal antibody,...
Conjugated via claimed linking group, bond, chelating agent,...
536 17A, 536 4, A61K 3171, C07H 1522
Patent
active
042846250
ABSTRACT:
Naphthacene derivatives of the formula: ##STR1## wherein each of R.sub.1 and R.sub.2 represents an oxygen atom or a group of the formula ##STR2## and R.sub.3 represents hydrogen, or an alkyl, alkanoyl, thioalkanoyl, aryl, aroyl, carbamoyl, thiocarbamoyl, methylthiocarbamoyl or amidino group, these groups being optionally substituted, and R.sub.4 represents hydrogen, or R.sub.3 and R.sub.4 together with the nitrogen atom to which they are attached represent piperazin-1-yl which carries on the second nitrogen atom an optionally substituted alkyl group, particularly 4-methoxy-5,12-dioxo-6,9,11-trihydroxy-7-(2,3,6-0-tridesoxy-3-amino-1-L-ly xohexosyl)-9-(1-formylhydrazono-ethyl)-5,7,8,9,10,12-hexahydro-naphthacene, and non-toxic salts thereof, posses anti-tumour properties.
REFERENCES:
patent: 3590028 (1971-06-01), Arcamone et al.
patent: 3686163 (1972-08-01), Arcamone et al.
Brown Johnnie R.
Rhone-Poulenc S.A.
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