Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1972-11-20
1976-06-22
Brown, Johnnie R.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
424180, C07H 1500
Patent
active
039650880
ABSTRACT:
Naphthacene derivatives of the formula: ##SPC1##
Wherein each of R.sub.1 and R.sub.2 represents an oxygen atom or a group of the formula ##EQU1## and R.sub.3 represents hydrogen, or an alkyl, alkanoyl, thioalkanoyl, aryl, aroyl, carbamoyl, thiocarbamoyl, methylthiocarbamoyl or amidino group, these groups being optionally substituted, and R.sub.4 represents hydrogen, or R.sub.3 and R.sub.4 together with the nitrogen atom to which they are attached represent piperazin-1-yl which carries on the second nitrogen atom an optionally substituted alkyl group, particularly 4-methoxy-5,12-dioxo-6,9,11-trihydroxy-7-(2,3,6-O-tridesoxy-3-amino-1-L-ly xohexosyl)-9-(1-formylhydrazono-ethyl)-5,7,8,9,10,12-hexahydro-naphthacene, and non-toxic salts thereof, possess anti-tumour properties.
REFERENCES:
patent: 3590028 (1971-06-01), Arcamone et al.
patent: 3686163 (1972-08-01), Arcamone et al.
Brown Johnnie R.
Rhone-Poulenc S.A.
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