Naphtenic and heterocyclic retinoic acid analogues

Details Naphtenic and heterocyclic retinoic acid analogues Naphtenic and heterocyclic retinoic acid analogues

1984-04-12

1985-05-21

Siegel, Alan

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514443, 549 57, 549 71, 549 72, 549467, 549468, 549484, 549487, 514461, 514469, 514471, A61K 3138, A61K 3134

Patent

active

045186090

ABSTRACT:
Naphthenic and heterocyclic retinoic acid analogues such as (E)-6-[2-(2,6,6-trimethyl-1-cyclohexen-1-yl)ethenyl]-2-naphthaldehyde, methyl 6-[2-(2,6,6-trimethyl-1-cyclohexen-1-yl)ethenyl]-2-naphthoate, 6-[2-(2,6,6-trimethyl-1-cyclohexen-1-yl)ethenyl]-2-naphthoic acid, (E)-1-(5-carbethoxy-2-furanyl)-2-methyl-4-(2,6,6-trimethyl-1-cyclohexen-1- yl)-1,3-butadiene, (E)-1-(5-carboxy-2-furanyl)-2-methyl-4-(2,6,6-trimethyl-1-cyclohexen-1-yl) -1,3-butadiene, (E)-1-(5-carbethoxythien-2-yl)-2-methyl-4-(2,6,6-trimethyl-1-cyclohexen-1- yl)-1,3-butadiene, and (E)-1-(5-carboxythien-2-yl)-2-methyl-4-(2,6,6-trimethyl-1-cyclohexen-1-yl) -1,3-butadiene. These retinoids are useful as chemopreventive agents for inhibiting tumor promotion in epithelial cells and for treating nonmalignant skin disorders.

REFERENCES:
patent: 4456618 (1984-06-01), Dawson et al.
Boutwell et al., Advances in Enzyme Regulation, vol. 17, (1979), pp. 89-112.
Verma et al., Cancer Res., vol. 39, (1979), pp. 419-427.
Dawson et al., J. Med. Chem., vol. 23, (1980), pp. 1013-1022.
Dawson et al., J. Med. Chem., vol. 24, (1981), pp. 583-592.

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