Nanowire assisted laser desorption/ionization mass...

Radiant energy – Ionic separation or analysis – With sample supply means

Reexamination Certificate

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C250S281000, C250S282000

Reexamination Certificate

active

07655902

ABSTRACT:
This invention relates to a nanowire-assisted method for mass spectrometric analysis of a specimen. More specifically, by using nanowire which can fix a specimen and perform desorption/ionization of the specimen while effectively transferring laser energy to the specimen to be irradiated, thereby enabling to perform mass spectrometric analysis without using a matrix solution. This invention, by effectively performing desorption/ionization of a specimen using the above-mentioned nanowire, enables to effectively perform qualitative-, quantitative-, and micro-analyses of specimens as well as low molecular weighted specimens. Further, this invention enables to the typical device of mass spectrometric analysis used in MALDI-T of MS. In particular, this invention can perform mass spectrometric analysis of a specimen with molecular weight of less than 1,000 Da and perform quantitative analysis by fixing a specimen with a predetermined area.

REFERENCES:
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patent: 2003/0052006 (2003-03-01), Noca et al.
patent: 2008/0073505 (2008-03-01), Niu et al.
patent: 08-315633 (1996-11-01), None
patent: 10-2001-0081780 (2003-06-01), None
Min-Jung Kang, et al., “Application of Automated Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry For The Measurement Of Enzyme Activities”, Rapid Commun. Mass Spectrom. 2001; 15: pp. 1327-1333.
Jing Wei, et al., “Desorption-Ionization Mass Spectrometry on Porous Silicon”, (1999) Nature, vol. 399, 243-246.
Warren G. Lewis, et al., Desorption/Ionization on Silicon (DIOS) Mass Spectrometry: Background and Applications, International Journal of Mass Spectrometry, 226 (2003) pp. 107-116.
Justin C. Johnson, et al., Single Gallium Nitride Nanowire Lasers, Nature Materials, vol. 1, Oct. 2002) pp. 106-110.
Vladimir E. Frankevich, “Role of Electrons in Laser Desorption/Ionization Mass Spectrometry”, Analytical Chemistry, vol. 75 No. 22, Nov. 15, 2003, pp. 6063-6067.
G/ Suizdak, 1. Ion Sources and Sample Introduction, In: Mass Spectroscopy for Biotechnology, Academic Press, 1996, p. 13.
J.M. Bermond, et al. Sur. Sci. 42 (1974) p. 306.

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