Nanostructured surfaces as a dual ionization LDI-DESI...

Details Nanostructured surfaces as a dual ionization LDI-DESI... Nanostructured surfaces as a dual ionization LDI-DESI...

2007-09-20

2010-12-28

Vanore, David A (Department: 2881)

Radiant energy

Ionic separation or analysis

Methods

C250S281000

Reexamination Certificate

active

07858928

ABSTRACT:
Embodiments of the invention include methods and devices for the analysis of proteins utilizing a gold coated nanoporous alumina surface for dual ionization mode mass spectrometric analysis using desorption electrospray ionization (DESI) and laser desorption ionization (LDI). Combined use of DESI and LDI gives increased sequence coverage in peptide mixture analysis from a single sample preparation.

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patent: 2009/0155678 (2009-06-01), Less et al.
Okuno et al., “Requirements for Laser-Induced Desorption/Ionization on Submicrometer Structures”, Analytical Chemistry, vol. 77, No. 16, Aug. 15, 2005, pp. 5364-5369.

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