Chemistry: analytical and immunological testing – Hemoglobin – myoglobin – or occult blood
Reexamination Certificate
2011-01-11
2011-01-11
Soderquist, Arlen (Department: 1797)
Chemistry: analytical and immunological testing
Hemoglobin, myoglobin, or occult blood
C356S301000, C422S082050, C422S082090, C436S086000, C436S094000, C436S164000, C436S166000, C436S171000, C436S501000, C436S514000, C436S525000
Reexamination Certificate
active
07867770
ABSTRACT:
The present invention provides a nanostructured substrate for SERS. A substrate of the invention comprises a surface featuring substantially monodisperse-sized metal nanoparticles disposed thereon. Preferably, the substrate surface provides for SERS and spectra therefrom. For example, a nanostructured substrate of the invention can be used to reproducibly and reliably detect or identify pathogens, molecules or combinations thereof. In one embodiment, a nanostructured substrate of the invention comprises a surface featuring metal nanoparticles substantially aggregated in clusters thereon. Exemplary metal nanoparticles disposed on the substrate surface can be silver, copper, gold or combinations thereof. Metal nanoparticles disposed on a substrate surface can also be substantially spheroidal comprising diameters in a range from about 40 to 120 nm. The invention also provides methods for syntheses and uses of a nanostructured substrate comprising a surface featuring substantially monodisperse-sized metal nanoparticles.
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Soderquist Arlen
Trustees of Boston University
Weingarten Schurgin, Gagnebin & Lebovici LLP
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