Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Patent
1995-02-09
1996-05-21
Cintins, Marianne M.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
A61K 916
Patent
active
055187382
ABSTRACT:
A composition comprising a crystalline NSAID having polyvinylpyrrolidone adsorbed on the surface thereof in an amount sufficient to maintain an effective average particle size of less than about 1000 nm, hygroscopic sugar and sodium lauryl sulfate exhibit greatly reduced gastric irritation following oral administration and/or hastened onset of action due to the substantial redispersion of the solid formulation to nanoparticles in gastric fluid.
REFERENCES:
patent: 5145684 (1992-09-01), Liversidge et al.
patent: 5183829 (1993-02-01), Caldwell
Cioli et al., "Toxicological and Applied Pharmacology", 50, 283-289 (1979).
Price et al, "Drugs", 40 (Suppl. 5): 1-11, 1990.
Eickhoff W. Mark
Engers David A.
Mueller Karl R.
Cintins Marianne M.
MacMillian Keith
NanoSystem L.L.C.
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