Nanoparticulate nsaid compositions

Details Nanoparticulate nsaid compositions Nanoparticulate nsaid compositions

1995-02-09

1996-05-21

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

A61K 916

Patent

active

055187382

ABSTRACT:
A composition comprising a crystalline NSAID having polyvinylpyrrolidone adsorbed on the surface thereof in an amount sufficient to maintain an effective average particle size of less than about 1000 nm, hygroscopic sugar and sodium lauryl sulfate exhibit greatly reduced gastric irritation following oral administration and/or hastened onset of action due to the substantial redispersion of the solid formulation to nanoparticles in gastric fluid.

REFERENCES:
patent: 5145684 (1992-09-01), Liversidge et al.
patent: 5183829 (1993-02-01), Caldwell
Cioli et al., "Toxicological and Applied Pharmacology", 50, 283-289 (1979).
Price et al, "Drugs", 40 (Suppl. 5): 1-11, 1990.

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