Nanoparticulate diagnostic dimers as x-ray contrast agents for b

Details Nanoparticulate diagnostic dimers as x-ray contrast agents for b Nanoparticulate diagnostic dimers as x-ray contrast agents for b

1995-02-10

1996-03-19

Hollinden, Gary E.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

X-ray contrast imaging agent

424 9451, 560 47, A61K 4904

Patent

active

055002048

ABSTRACT:
This invention relates to methods of x-ray diagnostic imaging the blood pool, liver, spleen and/or lymph system of a mammal comprising administering a contrast effective amount of a succinic acid derivative disubstituted with benzoic acid residue as a contrast agent having the structure: ##STR1## R.sup.1 and R.sup.2 are alkyl of from 2 to 18 carbon atoms; A.sub.r is ##STR2## R.sup.3 is selected from the group consisting of NCH.sub.2, NHAc, and ##STR3## wherein R is an alkyl of 1 to 10 carbon atoms;

REFERENCES:
patent: 3097228 (1963-07-01), Larsen
patent: 5318767 (1994-06-01), Liversidge et al.
patent: 5368837 (1994-11-01), Baker et al.
"Pharmaceuticals in Medical Imaging" by Swanson et al, MacMillan Publishing, New York, 1990.

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