Nanoparticulate compositions comprising copolymers of vinyl...

Details Nanoparticulate compositions comprising copolymers of vinyl... Nanoparticulate compositions comprising copolymers of vinyl...

2005-11-29

2005-11-29

Page, Thuman K. (Department: 1615)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

C424S451000, C424S464000

Reexamination Certificate

active

06969529

ABSTRACT:
The present invention is directed to nanoparticulate compositions comprising a poorly soluble drug and at least one copolymer of vinyl pyrrolidone and vinyl acetate as a surface stabilizer adsorbed to the surface of the drug. Also encompassed by the invention are pharmaceutical compositions comprising a nanoparticulate composition of the invention, methods of making and using such nanoparticulate and pharmaceutical compositions.

REFERENCES:
patent: 4540602 (1985-09-01), Motoyama et al.
patent: 4727077 (1988-02-01), Haga et al.
patent: 4783484 (1988-11-01), Violante et al.
patent: 4826689 (1989-05-01), Violante et al.
patent: 4851421 (1989-07-01), Iwasaki et al.
patent: 4904668 (1990-02-01), Kondo et al.
patent: 4983605 (1991-01-01), Kondo et al.
patent: 4997454 (1991-03-01), Violante et al.
patent: 5002952 (1991-03-01), Kondo et al.
patent: 5098907 (1992-03-01), Kondo et al.
patent: 5118528 (1992-06-01), Fessi et al.
patent: 5145684 (1992-09-01), Liversidge et al.
patent: 5264213 (1993-11-01), Shibahara et al.
patent: 5298262 (1994-03-01), Na et al.
patent: 5302401 (1994-04-01), Liversidge et al.
patent: 5318767 (1994-06-01), Liversidge et al.
patent: 5326552 (1994-07-01), Na et al.
patent: 5336507 (1994-08-01), Na et al.
patent: 5346702 (1994-09-01), Na et al.
patent: 5352459 (1994-10-01), Hollister et al.
patent: 5399363 (1995-03-01), Liversidge et al.
patent: 5401492 (1995-03-01), Kellar et al.
patent: 5429824 (1995-07-01), June
patent: 5447710 (1995-09-01), Na et al.
patent: 5451393 (1995-09-01), Liversidge et al.
patent: 5466433 (1995-11-01), Bacon et al.
patent: 5466440 (1995-11-01), Ruddy et al.
patent: 5470583 (1995-11-01), Na et al.
patent: 5472683 (1995-12-01), Illig
patent: 5494683 (1996-02-01), Liversidge et al.
patent: 5500204 (1996-03-01), Osifo et al.
patent: 5503723 (1996-04-01), Ruddy et al.
patent: 5510118 (1996-04-01), Bosch et al.
patent: 5518187 (1996-05-01), Bruno et al.
patent: 5518738 (1996-05-01), Eickhoff et al.
patent: 5521218 (1996-05-01), Osifo
patent: 5525328 (1996-06-01), Bacon et al.
patent: 5534270 (1996-07-01), De Castro
patent: 5543133 (1996-08-01), Swanson et al.
patent: 5552160 (1996-09-01), Liversidge et al.
patent: 5560931 (1996-10-01), Eickhoff et al.
patent: 5560932 (1996-10-01), Bagchi et al.
patent: 5565188 (1996-10-01), Wong et al.
patent: 5569448 (1996-10-01), Wong et al.
patent: 5571536 (1996-11-01), Eickhoff et al.
patent: 5573749 (1996-11-01), Illig
patent: 5573750 (1996-11-01), Singh
patent: 5580579 (1996-12-01), Ruddy et al.
patent: 5585108 (1996-12-01), Ruddy et al.
patent: 5587143 (1996-12-01), Wong
patent: 5591456 (1997-01-01), Franson et al.
patent: 5593657 (1997-01-01), Ruddy et al.
patent: 5595762 (1997-01-01), Derrieu et al.
patent: 5603916 (1997-02-01), Singh
patent: 5622938 (1997-04-01), Wong
patent: 5628981 (1997-05-01), Liversidge et al.
patent: 5643552 (1997-07-01), Illig
patent: 5662883 (1997-09-01), Bagchi et al.
patent: 5665330 (1997-09-01), Wong
patent: 5665331 (1997-09-01), Bagchi et al.
patent: 5668196 (1997-09-01), Robinson et al.
patent: 5670136 (1997-09-01), Bacon et al.
patent: 5716642 (1998-02-01), Bagchi et al.
patent: 5718388 (1998-02-01), Czekai et al.
patent: 5718919 (1998-02-01), Ruddy et al.
patent: 5741522 (1998-04-01), Violante et al.
patent: 5747001 (1998-05-01), Wiedmann et al.
patent: 5776496 (1998-07-01), Violante et al.
patent: 5834025 (1998-11-01), de Garavilla et al.
patent: 5862999 (1999-01-01), Czekai et al.
patent: 5891420 (1999-04-01), Cutie
patent: 5972389 (1999-10-01), Shell et al.
patent: 6045829 (2000-04-01), Liversidge et al.
patent: 6068858 (2000-05-01), Liversidge et al.
patent: 6153225 (2000-11-01), Lee et al.
patent: 6165506 (2000-12-01), Jain et al.
patent: 6264922 (2001-07-01), Wood et al.
patent: 6375986 (2002-04-01), Ryde et al.
patent: 6592903 (2003-07-01), Ryde et al.
patent: 0 262 560 (1987-09-01), None
patent: 0 818 450 (1998-01-01), None
patent: WO 93/13773 (1993-07-01), None
patent: WO 9313773 (1993-07-01), None
patent: 96/25918 (1996-08-01), None
patent: 98/35666 (1998-08-01), None
patent: 00/18374 (2000-04-01), None
patent: 00/27363 (2000-05-01), None
patent: WO 02/24163 (2002-03-01), None
Matsumoto et al., “Physical Properties of Solid Molecular dispersions of Indomethacin with Poly(vinylpyrrolidone) and Poly(vinylpyrrolidone-co-vinyl-acetate) in Relation to Indomethacin Crystallization,”Pharmaceutical Research(1999), vol. 16, No. 11, pp. 1722-1728, XP000987250.
Hülsmann et al., “Melt extrusion—an alternative method for enhancing the dissolution rate of 17β-estradiol hemihydrate,”European Journal of Pharmaceutics and Biopharmaceutics(2000), vol. 49, No. 3, pp. 237-242, XP004257163.
Vojnovic et al., “Formulation and evaluation of vinylpyrrolidone/vinylacetate copolymer microspheres and griseofuvin,”J. Microencapsulation(1993), vol. 10, No. 1, pp. 89-99, XP000334996.
Bogdanova et al., “Solid Dispersions of Isopropylantipyrin,”Labo-Pharma-Probl. Tech.(1984), vol. 32, No. 348, pp. 835-837, XP001097528.
Zingone et al., “Characterization and dissolution study of solid dispersions of theophylline and indomethacin with PVP/VA copolymers,”STP Pharma Sciences(1992), vol. 2, No. 2, pp. 186-192, XP002111752.
Kondo et al., “Improved Oral Absorption of Enteric Coprecipitates of a Poorly Soluble Drug,”Journal of Pharmaceutical Sciencesvol. 83, No. 4, Apr. 1994, pp. 566-570.
Kondo et al., “Improved Oral Absorption of a Poorly Water-Soluble Drug, HO-221, by Wet Bead Milling Producing Particles in Submicron Region,”Chemical&Pharmaceutical Bulletinvol. 41, No. 4, Apr. 1993, pp. 737-740.
Kondo et al., “Pharmacokinetics of a Micronized, Poorly Water-Soluble Drug, HO-221, in Experimental Animals,”Biological&Pharmaceutical Bulletinvol. 16, No. 8, Aug. 1993, pp. 796-800.
Plasdone® Povidone USP Technical Profile, International Specialty Products, 1999.
Plasdone® S-630 Technical Profile, International Speciality Products, 2000.
Kollidon® Grades Sheet, BASF.

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