Nanoparticles having oligonucleotides attached thereto and...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C536S022100, C536S023100, C536S024300, C536S026600

Reexamination Certificate

active

06962786

ABSTRACT:
The invention provides methods of detecting a nucleic acid. The methods comprise contacting the nucleic acid with one or more types of particles having oligonucleotides attached thereto. In one embodiment of the method, the oligonucleotides are attached to nanoparticles and have sequences complementary to portions of the sequence of the nucleic acid. A detectable change (preferably a color change) is brought about as a result of the hybridization of the oligonucleotides on the nanoparticles to the nucleic acid. The invention also provides compositions and kits comprising particles. The invention further provides methods of synthesizing unique nanoparticle-oligonucleotide conjugates, the conjugates produced by the methods, and methods of using the conjugates. In addition, the invention provides nanomaterials and nanostructures comprising nanoparticles and methods of nanofabrication utilizing nanoparticles. Finally, the invention provides a method of separating a selected nucleic acid from other nucleic acids.

REFERENCES:
patent: 4193983 (1980-03-01), Ullman et al.
patent: 4256834 (1981-03-01), Zuk et al.
patent: 4261968 (1981-04-01), Ullman et al.
patent: 4313734 (1982-02-01), Leuvering
patent: 4318707 (1982-03-01), Litman et al.
patent: 4650770 (1987-03-01), Liu et al.
patent: 4713348 (1987-12-01), Ullman
patent: 4853335 (1989-08-01), Olsen et al.
patent: 4868104 (1989-09-01), Kurn et al.
patent: 4996143 (1991-02-01), Heller et al.
patent: 5225064 (1993-07-01), Henkens et al.
patent: 5284748 (1994-02-01), Engelhardt et al.
patent: 5288609 (1994-02-01), Mroczkowski et al.
patent: 5294369 (1994-03-01), Shigekawa et al.
patent: 5360895 (1994-11-01), Hainfeld et al.
patent: 5384073 (1995-01-01), Shigekawa et al.
patent: 5384265 (1995-01-01), Kidwell et al.
patent: 5460831 (1995-10-01), Kossovsky et al.
patent: 5472881 (1995-12-01), Beebe et al.
patent: 5508164 (1996-04-01), Kausch et al.
patent: 5514602 (1996-05-01), Brooks, Jr. et al.
patent: 5521289 (1996-05-01), Hainfeld et al.
patent: 5543158 (1996-08-01), Gref et al.
patent: 5571726 (1996-11-01), Brooks, Jr. et al.
patent: 5599668 (1997-02-01), Stimpson et al.
patent: 5609907 (1997-03-01), Natan
patent: 5637508 (1997-06-01), Kidwell et al.
patent: 5665582 (1997-09-01), Kaushch et al.
patent: 5681943 (1997-10-01), Letsinger et al.
patent: 5751018 (1998-05-01), Alivisatos et al.
patent: 5830986 (1998-11-01), Merrill et al.
patent: 5900481 (1999-05-01), Lough et al.
patent: 5922537 (1999-07-01), Ewart et al.
patent: 5939021 (1999-08-01), Hansen et al.
patent: 5972615 (1999-10-01), An et al.
patent: 5990479 (1999-11-01), Weiss et al.
patent: 6025202 (2000-02-01), Natan
patent: 6149868 (2000-11-01), Natan et al.
patent: 6203989 (2001-03-01), Goldberg et al.
patent: 6214560 (2001-04-01), Yguerabide et al.
patent: 6251303 (2001-06-01), Bawendi et al.
patent: 6264825 (2001-07-01), Blackburn et al.
patent: 6277489 (2001-08-01), Abbott et al.
patent: 6306610 (2001-10-01), Bawendi et al.
patent: 6361944 (2002-03-01), Mirkin et al.
patent: 6365418 (2002-04-01), Wagner et al.
patent: 6417340 (2002-07-01), Mirkin et al.
patent: 6495324 (2002-12-01), Mirkin et al.
patent: 6506564 (2003-01-01), Mirkin et al.
patent: 6582921 (2003-06-01), Mirkin et al.
patent: 6602669 (2003-08-01), Mirkin et al.
patent: 6610491 (2003-08-01), Mirkin et al.
patent: 6645721 (2003-11-01), Mirkin et al.
patent: 6673548 (2004-01-01), Mirkin et al.
patent: 6677122 (2004-01-01), Mirkin et al.
patent: 6682895 (2004-01-01), Mirkin et al.
patent: 6709825 (2004-03-01), Mirkin et al.
patent: 6720147 (2004-04-01), Mirkin et al.
patent: 6720411 (2004-04-01), Mirkin et al.
patent: 6726847 (2004-04-01), Mirkin et al.
patent: 6730269 (2004-05-01), Mirkin et al.
patent: 6740491 (2004-05-01), Mirkin et al.
patent: 6750016 (2004-06-01), Mirkin et al.
patent: 6759199 (2004-07-01), Mirkin et al.
patent: 6767702 (2004-07-01), Mirkin et al.
patent: 6773884 (2004-08-01), Mirkin et al.
patent: 6777186 (2004-08-01), Mirkin et al.
patent: 2002/0137070 (2002-09-01), Mirkin et al.
patent: 2002/0155461 (2002-10-01), Mirkin et al.
patent: 2002/0160381 (2002-10-01), Mirkin et al.
patent: 2002/0177143 (2002-11-01), Mirkin et al.
patent: 2002/0192687 (2002-12-01), Mirkin et al.
patent: 2003/0054358 (2003-03-01), Mirkin et al.
patent: 2003/0068622 (2003-04-01), Mirkin et al.
patent: 2003/0068638 (2003-04-01), Mirkin et al.
patent: 2003/0087242 (2003-05-01), Mirkin et al.
patent: 2003/0113740 (2003-06-01), Mirkin et al.
patent: 2003/0124528 (2003-07-01), Mirkin et al.
patent: 2003/0129608 (2003-07-01), Mirkin et al.
patent: 2003/0143538 (2003-07-01), Mirkin et al.
patent: 2003/0143598 (2003-07-01), Mirkin et al.
patent: 2003/0148282 (2003-08-01), Mirkin et al.
patent: 2003/0207296 (2003-11-01), Mirkin et al.
patent: 2003/0211488 (2003-11-01), Mirkin et al.
patent: 2004/0038255 (2004-02-01), Mirkin et al.
patent: 2004/0053222 (2004-03-01), Mirkin et al.
patent: 2004/0072231 (2004-04-01), Mirkin et al.
patent: 2004/0086897 (2004-05-01), Mirkin et al.
patent: 2004/0101889 (2004-05-01), Mirkin et al.
patent: 0 630 974 (1994-06-01), None
patent: 0 667 398 (1995-08-01), None
patent: WO 89/06801 (1989-07-01), None
patent: WO 90/02205 (1990-03-01), None
patent: WO 92/04469 (1992-03-01), None
patent: WO 93/10564 (1993-05-01), None
patent: WO 93/25709 (1993-12-01), None
patent: WO 94/29484 (1994-12-01), None
patent: WO 97/40181 (1997-10-01), None
patent: WO 98/04740 (1998-02-01), None
patent: WO 98/04740 (1998-02-01), None
patent: WO 98/10289 (1998-03-01), None
patent: WO 98/17317 (1998-04-01), None
patent: WO 99/23258 (1998-10-01), None
patent: WO 99/20789 (1999-04-01), None
patent: WO 99/21934 (1999-05-01), None
patent: WO 99/23258 (1999-05-01), None
patent: WO 99/60169 (1999-11-01), None
patent: WO 00/25136 (2000-05-01), None
patent: WO 00/33079 (2000-06-01), None
patent: WO 01/00876 (2001-01-01), None
patent: WO 01/00876 (2001-01-01), None
patent: WO 01/51665 (2001-07-01), None
patent: WO 01/051665 (2001-07-01), None
patent: WO 01/73123 (2001-10-01), None
patent: WO 01/073123 (2001-10-01), None
patent: WO 01/86301 (2001-11-01), None
patent: WO 02/04681 (2002-01-01), None
patent: WO 02/004681 (2002-01-01), None
patent: WO 02/18643 (2002-03-01), None
patent: WO 02/018643 (2002-03-01), None
patent: WO 02/36169 (2002-05-01), None
patent: WO 00/33079 (2002-06-01), None
patent: WO 02/46472 (2002-06-01), None
patent: WO 02/46483 (2002-06-01), None
patent: WO 02/046472 (2002-06-01), None
patent: WO 02/079490 (2002-10-01), None
patent: WO 02/096262 (2002-12-01), None
patent: WO 2003/008539 (2003-01-01), None
patent: WO 2003/035829 (2003-05-01), None
patent: WO 2003/081202 (2003-10-01), None
patent: WO 2003/087188 (2003-10-01), None
patent: WO 2003/095973 (2003-11-01), None
patent: WO 2004/004647 (2004-01-01), None
patent: WO 2004/053105 (2004-06-01), None
O.D. Velev, et al., “In Situ Assembly of Collordal Particles into Miniatured Biosensors,”Langmuir,vol. 15, No. 11, pp. 3693-3698, May 25, 1999.
Mohanty J., et al. “Pulsed laser excitation of phosphate stabilized silver nanoparticles,”Proc. Indian Acd. Sci.,vol. 112, No. 1, p. 63-72.
Nicewarner- Peńa S., et al., “Hybridization and Enzymatic Extension of Au Nanoparticle-Bound Oligonucleotides,”J. Am. Chem. Soc.,vol. 24, p. 7314-7323 (2002).
Whitesides G.M., et al., “Soft Lithography in Biology and Biochemistry,”Annu. Rev. Biomed. Eng.,p. 335-373 (2001).
Stimpson, et al., “Real-time detection of DNA hybridization and melting on oligonucleotide arrays by using optical wave guides,”Proc. Natl. Acad. Sci.,vol. 92, pp. 6379-6383, California Institute of Technology (1995) U.S.
Storhoff, et al., “Strategies for Organizing Nanoparticles into Aggregate Structures and Functional Materials,”Journal of Cluster Science,vol. 8, No. 2, pp. 179-217, Plenum Publishing Corporation (1997) U.S.
Storhoff, et al., “One-Pot Colorimetric Differentiation of Polynucleotides with Single Base Imperfections Using Gold Nanoparticle Probes,”J. Am. Chem. Soc.,vol. 20, pp. 1961-1964, America

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Nanoparticles having oligonucleotides attached thereto and... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Nanoparticles having oligonucleotides attached thereto and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nanoparticles having oligonucleotides attached thereto and... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3495597

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.