Nanoparticles for targeting hepatoma cells and delivery means

Details Nanoparticles for targeting hepatoma cells and delivery means Nanoparticles for targeting hepatoma cells and delivery means

2011-07-26

2011-07-26

Monshipouri, Maryam (Department: 1656)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

Reexamination Certificate

active

07985426

ABSTRACT:
The invention discloses a system, method and pharmaceutical composition of nanoparticles for lodging in a target tissue cell in situ of an animal subject, the nanoparticles comprising PGA-PLA block copolymers that are conjugated with a ligand, wherein the ligand has ligand-receptor binding affinity for the ligand to bind a surface receptor of the tissue cell.

REFERENCES:
patent: 6177274 (2001-01-01), Park et al.
patent: 7534449 (2009-05-01), Saltzman et al.
patent: 2002/0132788 (2002-09-01), Lewis et al.
Williams H, “Steric sffects of multivalent ligand-receptor binding: Exclusion of ligand sites by bound cell surface receptors”.
LookSmart, Biophysical Journal Jun. 1999.

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