Nanoparticles for targeting hepatoma cells

Details Nanoparticles for targeting hepatoma cells Nanoparticles for targeting hepatoma cells

2008-03-25

2008-03-25

Monshipouri, Maryam (Department: 1656)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

C424S497000, C514S055000

Reexamination Certificate

active

11267848

ABSTRACT:
The nanoparticles composed of γ-PGA-PLA block copolymers that are conjugated with galactosamine as a potential drug delivery system and loaded with anticancer drugs for treating liver cancers.

REFERENCES:
patent: 6623729 (2003-09-01), Park et al.
Li C Poly(L-glutamic acid)-anticancer drug conjugates, Adv Drug Deliver Rev 2002;54695-713.
Na K et al. Self-assembled hydrogel nanoparticles from curdlan derivatives, J Control Release 2000;69:225-236.
Saul JM et al. Controlled targeting of liposomal doxorubicin via the folate receptor in vitro, J Control Release 2003; 92:49-67.
Liang HC et al. Genipin-crosslinked gelatin microspheres as a drug carrier for intramuscular administration, J Biomed Mater Res 2003; 65A:271-282.
Na K et al. Self-assembled nanoparticles of hydrophobically-modified polysaccharide bearing vitamin H as a targeted anti-cancer drug delivery system, Eur J Pharm Sci 2003;18:165-173.
Liang HF et al, Preparation of nanoparticles composed of poly(gamma-glutamic acid)-poly(lactide) block copolymers and evaluation of their uptake by HepG2 cells, J Control Release 2005;105:213-225.
Richard A et al. Poly(glutamic acid) for biomedical applications, Crit Rev Biotechnol 2001;21:219-232.
Prodhomme EJF et al. Multivalent conjugates of poly-gamma-D-glutamic acid fromBascillus licheniformiswith antibody F(ab') and glycopeptide ligands, Bioconjug Chem 2003;14:1148-1155.
Rao S et al. Characterization of Taxol binding site on the microtubule, 2-(M-Azidobenzoyl) Taxol photolabels a peptide (amino acids 217-231) of beta-tubulin, J Biol Chem 1995;270:20235-20238.
Gagandeep S et al. Paclitaxel shows cytotoxic activity in human hepatocellular carcinoma cell lines, Cancer Lett 1999;136:109-118.
Jordan MA et al. Mitotic block induced in HeLa cells by low concentrations of paclitaxel results in abnormal mitotic exit and apoptotic cell death, Cancer Res 1996;56:816-825.
Lee IH et al. Stable paclitaxel formulations in oily contrast medium, J Control Release 2005;102:415-425.
Lin HL et al. Comparison of 2-methoxyestradiol-induced, docetaxel-induced, and paclitaxel-induced apoptosis in hepatoma cells and its correlation with reactive oxygen species, Cancer 2000;89:983-994.
Kang TH et al. Antiproliferative effect of alkaloids fromSedum sarmentosumon murine and human hepatoma cell line, J Ethnopharmacol 2000;70:177-182.
Yoon SH et al. Production of poly-gamma-glutamic acid by fed-batch culture ofBascillus licheniformis, Biotechnol Lett 2000;22:585-588.
Troy FA, Chemistry and biosynthesis of the poly(gamma-D-glutamyl) capsule inBascillus licheniformisII. Characterization and structural properties of the enzymatically synthesized polymer, J Biol Chem 1973;248:316-324.
van Dijk-Wolthuis WNE et al. A new class of polymerizable destrans with hydrolysable groups: Hydroxyethyl methacrylated dextran with and without oligolactate spacer, Polymer 1997;38:6235-6242.
Gref R et al. Stealth corona-core nanoparticles surface modified by polyethylene glycol: Influences of the corona and of the core composition on phagocytic uptake and plasma protein adsorption, Colloid Surface B 2000;18:301-313.
Dong Y et al. Methoxy poly(ethylene glycol)-poly(lactide) nanoparticles for controlled delivery of anticancer drugs, Biomaterials 2004;25:2843-2849.
Zhang L et al. Camptothecin derivative-loaded poly(caprolactone-colactide)-b-PEG-b-poly(caprolactone-co-lactide) nanoparticles and their biodistribution in mice, J Control Release 2004;96:135-148.
Sung HW et al. Crosslinking of biological tissue using genipin and/or carbodiimide, J Biomed Mat Res 2003;64A:427-438.
Liang HC et al. Crosslinking structures of gelatin hydrogels crosslinked with genipin or a water-soluble carbodiimide, J Appl Polym Sci 2004;91:4017-4026.
David A et al. Enhanced biorecognition and internalization of HPMA copolymers containing multi- or multivalent carbohydrate side-chains by human hepatocarcinoma cells, Bioconjug Chem 2001;12:890-899.
Chen CN et al. Feasibility study using a natural compound (reuterin) produced byLactobacillus reuterinin sterilizing and crosslinking biological tissues, J Biomed Mater Res 2002;61:360-369.
Saito T et al. The effect of cell cycle on GFPuv gene expression in the baculovirus expression system, J Biotechnol 2002;93:121-129.
Hashida M et al. Targeted delivery of plasmid DNA complexed with galactosylated poly(L-lysine), J Control Release 1998;53:301-310.
Litzinger DC et al. Effect of liposome size on the circulation time and intraorgan distribution of amphipathic poly(ethylene glycol)-containing liposomes, Biochim Biophys Acta 1994;1190:99-107.
Maeda H et al. Tumoritropic and lymphotropic principles of macromolecular drugs, Crit Rev Ther Drug Carrier Syst 1989;6:193-210.
Wakebayashi D et al. Lactose-conjugated polyion complex micelles incorporating plasmid DNA as a taragetable gene vector system: their preparation and gene transfering efficiency against cultured HepG2 cells, J Control Release 2004;95:653-664.
Ward CM et al. Systemic circulation of poly(L-lysine)/DNA vectors is influenced by polycation molecular weight and type of DNA: differential circulation in mice and rats and the implications for human gene delivery, Blood 2001;97:2221-2229.
Lee SC et al. Polymeric micelles of poly(2-ethyl-2-oxazoline)-block-poly (episilon-caprolactone) copolymer as a carrier for paclitaxel, J Control Release 2003;89:437-446.
Gref R et al. Biodegradable long-circulating polymeric nenoparticles, Science 1994;263:1600-1603.
Han JH et al. Enhanced hepatocyte uptake and liver targeting of methotrexate using galactosylated albumin as a carrier, Int J Pharm 1999;188:39-47.
Chao Y et al. Phase II and pharmacokinetic study of paclitaxel therapy for unresectable hepatocellular carcinoma patients, Br J Cancer 1998;78:34-39.
Yoon CJ et al. Transcatheter arterial chemoembolization with paclitaxel-lipiodol solution in rabbit VX2 liver tumor, Radiology 2003;229:126-131.
Fuchs J et al. Paclitaxel: an effective antineoplastic agent in the treatment of xenotransplanted hepatoblastoma, Med Pediatr Oncol 1999;32:209-215.
Yuan JH et al. Growth-inhibiting effects of Taxol on human liver cancer in vitro and in nude mice, World J Gastroenterol 2000;6:210-215.
Matsumura Y et al. A new concept for macromolecular therapeutics in cancer chemotherapy: nechanism of tumoritropic accumulation of proteins and the antitumor agent smances, Cancer Res 1986;46:6387-6392.
Hashida M et al. Design of polymeric prodrugs of prostaglandin E1 having galactose residue for hepatocyte targeting, J Control Release 1999;62:253-262.
Son YJ et al. Biodistribution and anti-tumor efficiency of doxorubicin loaded glycol-chitosan nanoaggregates by EPR effect J Control Release 2003;91:135-145.
Kim SC et al. In vitro evaluation of polymeric micellar paclitaxel formulation:toxicity and efficacy, J Control Release 2001;72:191-202.
Garrec DL et al. Poly(N-vinylpyrrolidone)-block-poly(D,L-lactide) as a new polymeric solubilizer for hydrophobic anticancer drugs, J Control Release 2004;99:83-101.

Affiliated with

Also associated with

Rating

Nanoparticles for targeting hepatoma cells does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Nanoparticles for targeting hepatoma cells, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nanoparticles for targeting hepatoma cells will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3929536