Nanoparticles for targeting hepatoma cells

Details Nanoparticles for targeting hepatoma cells Nanoparticles for targeting hepatoma cells

2007-12-04

2007-12-04

Monshipouri, Maryam (Department: 1656)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S012200

Reexamination Certificate

active

11328552

ABSTRACT:
A dual-particle tumor targeting system comprising a first ligand-mediated targeting nanoparticle conjugated with galactosamine and a second EPR-mediated targeting nanoparticle, wherein said first and second nanoparticles are mixed in a solution configured for delivering to a target liver tumor.

REFERENCES:
patent: 6177274 (2001-01-01), Park et al.
Liang HF et al. “Preparation of nanoparticles composed of poly(γ-glutamic acid)-poly(lactide) block copolymers and evaluation of their uptake by HepG2 cells” Journal of Controlled Release 2005; 105:213-225.
Son YJ et al. “Biodistribution and multi-tumor efficacy of doxorubicin loaded glycol-chitosan nanoaggregates by EPR effect” Journal of Controlled Release 2003;91:135-145.
Han JH et al. “Enhanced hepatocyte uptake and liver targeting of methotrexate using galactosylated albumin as a carrier” International Journal of Pharmaceutics 1999;188:39-47.
Hashida M et al. Targeted delivery of plasmid DNA complexed with galacyosylated poly(L-lysine) Journal of Controlled Release 1998;53:301-310.
Na K et al. “Self-assembled hydrogel nanoparticles from curdian derivatives: characterization, anti-cancer drug release and interaction with a hepatoma cell line (HepG2)” Journal of Controlled Release 2000;69:225-236.
Li C “Poly(L-glutamic acid)-anticancer drug conjugates” Advanced Drug Delivery Reviews 2002;54:695-713.

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