Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Reexamination Certificate
2011-03-08
2011-03-08
Cordero Garcia, Marcela M (Department: 1654)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
Reexamination Certificate
active
07901711
ABSTRACT:
The invention discloses the biodegradable nanoparticle for use in nanoparticle projectile bombardment as a carrier for administering proteins, peptides or siRNAs transdermally to an animal subject. The nanoparticles are composed of positively charged chitosan substrate, negatively charged core substrate complexed with chitosan, and encapsulated bioactive agents.
REFERENCES:
patent: 4749620 (1988-06-01), Rha et al.
patent: 5899880 (1999-05-01), Bellhouse et al.
patent: 6146663 (2000-11-01), Bissery et al.
patent: 6194389 (2001-02-01), Johnston et al.
patent: 6458387 (2002-10-01), Scott et al.
patent: 6475995 (2002-11-01), Roy et al.
patent: 6989195 (2006-01-01), Anderson
patent: 7345027 (2008-03-01), Tolentino et al.
patent: 7381716 (2008-06-01), Sung et al.
patent: 7449200 (2008-11-01), Sung et al.
patent: 7455830 (2008-11-01), Sung et al.
patent: 7541028 (2009-06-01), Sung et al.
patent: 7541046 (2009-06-01), Sung et al.
patent: 7556826 (2009-07-01), Sung et al.
patent: 7604795 (2009-10-01), Sung et al.
patent: 7611690 (2009-11-01), Sung et al.
Park et al. Galactosylated chitosan-graft-dextran as hepatocyte-targeting DNA carrier. J Controlled Release, 2000, vol. 69, pp. 97-108.
Borchard. Chitosans for gene delivery. Advanced Drug Delivery Reviews. 2001. vol. 52, pp. 145-150.
Mi et al. Fabrication of chondroitin sulfate-chitosan composite artificial extracellular matrix for stabilitzation of fibroblast growth factor. J Biomed Mater Res, 2006, 76A, pp. 1-15.
Andersson et al. Small particles of a heaprin/chitosan complex prepared from a pharmacuetically acceptable microemulsion. Int. J of Pharmaceutics. 2003. vol. 257, pp. 305-309.
Lin Yh et al., “Novel nanoparticles for oral insulin delivery via the paracellular pathway” Nanotechnology 2007;18:1-11 .
Ogura M et al., “In vivo targeted gene transfer in skin by the use of laser-induced stress waves” Lasers Surg. Med. 2004;34:242-248.
Douglas KL et al., “Effects of alginate inclusion on the vector properties of chitosan-based nanoparticles” J. Control. Release 2006;115:354-361.
Soppimath KS et al., “Biodegradable polymeric nanoparticles as drug delivery devices” J. Control. Release 2001;70:1-20.
Mikszta JA et al., “Improved genetic immunization via micromechanical disruption of skin-barrier function and targeted epidermal delivery” Nature Medicine 2002;8:415-419.
Roy K et al., “Oral gene delivery with chitosan-DNA nanoparticles generates immunologic protection in a murine model of peanut allergy” Nature Medicine 1999;5:387-391.
Qaqish RB et al., “Synthesis of a fluoroscent chitosan derivative and its application for the study of chitosan-mucin interactions” Carbohy. Polym. 1999;38:99-107.
Corsi K et al., Mesenchymal stem cells, MG63 and HEK293 transfection using chitosan-DNA nanoparticles Biomaterials 2003;24:1255-1264.
Liu W et al., “An investigation of the physicochemical properties of chitosan/DNA polyelectrolyte complexes” Biomaterials 2005;26 2705-2711.
Ye H et al., “Poly(r,L-glutamic acid)-cisplatin conjugate effectively inhibits human breast tumor xenografted in nude mice” Biomaterials 2006;27:5958-5965.
Erbacher P et al., “Chitosan-based vector/DNA complexes for gene delivery: biophysical characteristics and transfection ability” Pharma. Res. 1998;15:1332-1339.
Mao HQ et al., “Chitosan-DNA nanoparticles as gene carriers: synthesis, characterization and transfection efficiency” J. Control. Release 2001;70:399-421.
Cui Z et al., “Chitosan-based nanoparticles for topical genetic immunization” J Control. Release 2001;75:409-419.
Hsu WL et al., “Thermally-induced order-order transition of DNA-cationic surfactant complexes” Langmuir 2006;22:7521-7527.
Dang JM et al., “Natural polymers for gene delivery and tissue engineering” Adv. Drug Deliv. Rev. 2006;58:487-499.
Chen Mei-Chin
Lee Po-Wei
Sung Hsing-Wen
Tu Hosheng
Cordero Garcia Marcela M
GP Medical, Inc.
National Tsing Hua University
LandOfFree
Nanoparticles for protein/peptide delivery and delivery... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Nanoparticles for protein/peptide delivery and delivery..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nanoparticles for protein/peptide delivery and delivery... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2743562