Nanoparticles for protein drug delivery

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

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Reexamination Certificate

active

07871988

ABSTRACT:
The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one protein drug or bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular protein drug and bioactive agent delivery.

REFERENCES:
patent: 6383478 (2002-05-01), Prokop et al.
patent: 6649192 (2003-11-01), Fernandez et al.
patent: 6726934 (2004-04-01), Prokop
patent: 2001/0031260 (2001-10-01), Lee et al.
patent: 2006/0051423 (2006-03-01), Heppe et al.
Lin YH et al. “Preparation and characterization of nanoparticles shelled with chitosan for oral insulin delivery” Biomacromolecules 2007;8:146-152.
Lin YH et al. “Novel nanoparticles for oral insulin delivery via the paracellular pathway” Nanotechnology 2007;18:1-11.
van der Lubben IM et al. “Chitosan and its derivatives in mucosal drug and vaccine delivery” Euro J Pharma Sci 2001;14:201-207.
Hosny EA et al. “Oral delivery of insulin from enteric-coated capsules containing sodium salicylate” Int J Pharmaceutics 2002;237:71-76.
Thanou M et al. “Chitosan and its derivatives as intestinal absorption enhancers” Adv. Drug Deliv. Rev. 2001;50:S91-S101.
Smith J et al. “Effect of chitosan on epithelial cell tight junctions” Pharmaceutical Research 2004;21:43-49.
Lin YH et al. “Preparation of nanoparticles composed of chitosan/poly-gamma-glutaraldehyde and evaluation of their permeability through Caco-2 cells” Biomacromolecules 2005;6:1104-1112.
Fernandez-Urrusuno R et al. “Enhancement of nasal absorption of insulin using chitosan nanoparticles” Pharmaceutical Research 1999;16:1576-1581.
Mi FL et al. “Oral delivery of peptide drugs using nanoparticles self-assembled by poly(r-glutamic acid) and a chitosan derivative functionalized by trimethylation” Bioconjugate Chem 2008;19:1248-1255.
Minn A et al. “Drug transport into the mammalian brain:the nasal pathway and its specific metabolic barrier” J Drug Targeting 2002;10:285-296.
Vyas TK et al. “Intranasal mucoadhesive microemulsions of clonazepam: preliminary studies on brain targeting” J Pharma Sci 2006;95:570-580.
Hussar P et al. “The glucose transporter GLUT1 and the tight junction protein occludin in nasal olfactory mucosa” Chem Senses 2002;27:7-11.
Ma Z et al. “Uptake of chitosan and associated insulin in Caco-2 cell monolayers:a comparison between chitosan molecules and chitosan nanoparticles” Pharmaceutical Research 2003;20:1812-1819.

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