Nanoparticles for protein drug delivery

Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – In an organic compound

Reexamination Certificate

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C424S501000, C424S001730

Reexamination Certificate

active

07910086

ABSTRACT:
The invention discloses a pharmaceutical composition of bioactive nanoparticles composed of chitosan, poly-glutamic acid, and a bioactive agent for oral delivery. The chitosan-based nanoparticles are characterized with a positive surface charge and enhanced permeability for oral drug delivery.

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patent: 2006/0051423 (2006-03-01), Heppe et al.
Lin YH et al. “Preparation and characterization of nanoparticles shelled with chitosan for oral insulin delivery” Biomacromolecules 2007;8:146-152.
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van der Lubben IM et al. “Chitosan and its derivatives in mucosal drug and vaccine delivery” Euro J Pharma Sci 2001;14:201-207.
Hosny EA et al. “Oral delivery of insulin from enteric-coated capsules containing sodium salicylate” Int J Pharmaceutics 2002;237:71-76.
Thanou M et al. “Chitosan and its derivatives as intestinal absorption enhancers” Adv. Drug Deliv. Rev. 2001;50:S91-S101.
Smith J et al. “Effect of chitosan on epithelial cell tight junctions” Pharmaceutical Research 2004;21:43-49.
Mi FL et al. “Oral delivery of peptide drugs using nanoparticles self-assembled by poly(r-glutamic acid) and a chitosan derivative functionalized by trimethylation” Bioconjugate Chem 2008;19:1248-1255.

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