Nanoparticles for protein drug delivery

Details Nanoparticles for protein drug delivery Nanoparticles for protein drug delivery

2008-08-07

2009-11-03

Monshipouri, Maryam (Department: 1656)

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

In an organic compound

Reexamination Certificate

active

07611690

ABSTRACT:
The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one protein drug or bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular protein drug and bioactive agent delivery.

REFERENCES:
patent: 6383478 (2002-05-01), Prokop et al.
Lin Yh et al. “Preparation and characterization of nanoparticles shelled with chitosan for oral insulin delivery” Biomacromolecules 2007;8:146-152.
Lin Yh et al. “Novel nanoparticles for oral insulin delivery via the paracellular pathway” Nanotechnology 2007;18:1-11.
Lin Yh et al. “Preparation of nanoparticles composed of chitosan/poly-gamma-glutamic acid and evaluation of their permeability through Caco-2 cells” Biomacromolecules 2005;6:1104-1112.
Smith J et al. “Effect of chitosan on epothelial cell tight junctions” Pharmaceutical Research 2004;21:43-49.
Thanou M et al. “Chitosan and its derivatives as intestinal absorption enhancers” Adv. Drug Deliv. Rev. 2001;50:S91-S101.

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