Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Biocides; animal or insect repellents or attractants
Reexamination Certificate
2008-05-05
2009-06-02
Monshipouri, Maryam (Department: 1656)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Biocides; animal or insect repellents or attractants
Reexamination Certificate
active
07541046
ABSTRACT:
The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one protein drug or bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular protein drug and bioactive agent delivery.
REFERENCES:
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Lin YH et al. “Preparation and characterization of nanoparticles shelled with chitosan for oral insulin delivery” Biomacromolecules 2007;8:146-152.
Lin YH et al. “Novel nanoparticles for oral insulin delivery via the paracellular pathway” Nanotechnology 2007;18:1-11.
van der Lubben IM et al. “Chitosan and its derivatives in mucosal drug and vaccine delivery” Eur. J. Pharmaceu. Sci. 2001;14:201-207.
Hosny EA et al. “Oral delivery of insulin from enteric-coated capsules containing sodium salicylate:effect on relative hypoglycemia of diabetic beagle dogs” International J. Pharm. 2002;237:71-76.
Thanou M et al. “Chitosan and its derivatives as intestinal absorption enhancers” Adv. Drug Deliv. Rev. 2001;50:S91-S101.
Smith J et al. “Effect of chitosan on epithelial cell tight junctions” Pharmaceutical Research 2004;21:43-49.
Chen Mei-Chin
Liang Hsiang-Fa
Lin Yu-Hsin
Sung Hsing-Wen
Tu Hosheng
GP Medical, Inc.
Monshipouri Maryam
National Tsing Hua University
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