Nanoparticles for protein drug delivery

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C424S499000, C424S001330

Reexamination Certificate

active

11398440

ABSTRACT:
The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular drug delivery.

REFERENCES:
patent: 6726934 (2004-04-01), Prokop
patent: 2005/0226938 (2005-10-01), Borbely et al.
patent: 2006/0013885 (2006-01-01), Nah et al.
patent: 2006/0051423 (2006-03-01), Heppe et al.
Lin Yh et al., “Preparation of nanoparticles composed of chitosan/poly-r-glutamic acid and evaluation of their permeability through Caco-2 cells” Biomacromolecules 2005;6:1104.
Calceti P et al. “Development and in vivo evaluation of an oral insulin-PEG delivery system” Eur J Pharma Sci 2004;22:315-323.
Krauland Ah et al. “Oral insulin delivery: the potential of thiolated chitosan-insulin tablets on non-diabetic rats” J Controlled Release 2004;95:547-555.
Morcol T et al. “Calcium phosphate-PEG-insulin-casein particles as oral delivery systems for insulin” Int J Pharma 2004;277:91-97.
Rosa GD et al. “Influence of the co-encapsulation of different non-ionic surfactants on the properties of PLGA insulin-loaded microspheres” J Control. Release 2000;69:283-295.
Pan Y et al. “Relationship between drug effects and particle size of insulin-loaded bioadhesive microspheres” Acta Pharmacol Sin 2002;23:1051-1056.
Pan Y et al. “Bioadhesive polysaccharide in protein delivery system: chitosan nanoparticles improve the intestinal absorption of insulin in vivo” Int J Pharma 2002;249:139-147.
Lowe Pi et al. “Calcitonin and insulin in isobutylcyanoacrylate nanocapsules: protection against proteases and effect on intestinal absorption in rats” J. Pharm. Pharmacol. 1994;46:547-552.
Florence At et al. “The oral absorption of micro- and nanoparticulates: neither exceptional nor unusual” Pharmaceutical Research 1997;14:259-266.
Desai Mp et al. “Gastrointestinal uptake of niodegradable microparticles:effect of particle size” Pharmaceutical Research 1996;13:1838-1845.
Ma Z et al. “Formulation pH modulates the interaction of insulin with chitosan nanoparticles” J Pharm. Sci. 2002;91:1396-1404.
Hosny Ea et al. “Oral delivery of insulin from enteric-coated capsules containing sodium salicylate:effect on relative hypoglycemia of diabetic beagle dogs” International J. Pharm. 2002;237:71-76.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Nanoparticles for protein drug delivery does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Nanoparticles for protein drug delivery, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nanoparticles for protein drug delivery will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3835329

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.