Nanoparticles for protein drug delivery

Details Nanoparticles for protein drug delivery Nanoparticles for protein drug delivery

2011-08-09

2011-08-09

Monshipouri, Maryam (Department: 1656)

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

In an organic compound

C424S001730

Reexamination Certificate

active

07993624

ABSTRACT:
The invention discloses nanoparticles composed of chitosan, poly-glutamic acid, and at least one bioactive agent characterized with a positive surface charge. The bioactive agent is hydrophobic or lipophilic in nature and is associated with micelles before being encapsulated in nanoparticles.

REFERENCES:
patent: 6649192 (2003-11-01), Fernandez et al.
patent: 6726934 (2004-04-01), Prokop
patent: 2006/0051423 (2006-03-01), Heppe et al.
Thanou M et al. “Chitosan and its derivatives as intestinal absorption enhancers” Adv. Drug Deliv. Rev. 2001;50:S91-S101.
Smith J et al. “Effect of chitosan on epithelial cell tight junctions” Pharmaceutical Research 2004;21:43-49.

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