Nanoparticles

Details Nanoparticles Nanoparticles

2008-02-29

2011-12-20

Chin, Chris L (Department: 1641)

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

Carrier is inorganic

C424S193100

Reexamination Certificate

active

08080431

ABSTRACT:
Materials and methods for studying and modulating the interaction of carbohydrate-containing moieties with other species are described, in particular, small particles, e.g. clusters of metal or semiconductor atoms, which can be employed as a substrate for immobilising a plurality of ligands comprising carbohydrate groups. These “nanoparticles” can then be used to study carbohydrate mediated interactions, e.g. with other carbohydrates or proteins, and as therapeutics and diagnostic reagents.

REFERENCES:
patent: 4313734 (1982-02-01), Leuvering
patent: 5248772 (1993-09-01), Siiman et al.
patent: 5766572 (1998-06-01), Hasegawa et al.
patent: 6132750 (2000-10-01), Perrier et al.
patent: 0 465 081 (1992-01-01), None
patent: 05 02 6069 (2001-10-01), None
patent: 2 777 193 (1998-04-01), None
patent: 83/00173 (1983-05-01), None
patent: 89/03675 (1989-05-01), None
patent: 95/31220 (1995-11-01), None
patent: 99/61911 (1999-12-01), None
patent: 01/73123 (2001-10-01), None
Liu, Jian et al., “Cyclodextrin-Modified Gold Nanospheres. Host-Guest Interactions at Work to Control Colloidal Properties”, Journal of the American Chemical Society (1999), vol. 121, pp. 4304-4305.
Bell, G.I., et al. “Cell Adhesion: Competition Between Nonspecific Repulsion and Specific Binding”. Biophys. J. 45: 1051-1064 (1984).
Houseman B.T., et al. “The Role of Ligand Density in the Enzymatic Glycosylation of Carbohydrates Presented on Self-Assembly Monolayers of Alkanethiolates on Gold.” Angew. Chem. Int. Ed. 38(6): 782-785(1999).
Yarema K.J., et al., “Chemical Approaches to Glycobiology and Emerging Carbohydrate-Based Therapeutic Agents.” Curr. Opin, chem. Biol. 2(1): 49-61(1998).
Moore et al., “Tumoral Distribution of Long-Circulating Dextran-Coated Iron Oxide Nanoparticles in a Rodent Model”, Radiology 2000 United States, vol. 214, Nov. 2, 2000, pp. 568-574.
Tromas, C., et al. “Adhesion Forces Between Lewis Determinant Antigens As Measured by Atomic Force Microscopy”, Angew. Chem. Int. Ed. 2001, 40, No. 16, pp. 3052-3055.
de la Fuente, et al. “Gold Glyconanoparticles as Water-Soluble Polyvalent Models to Study Carbohydrate Interactions”, Angew. Chem. Int. Ed. 2001, 40, No. 12, pp. 2258-2261.
WPI Accession No. 1996-010697/01 (Abstract).
Ada, “Vaccines and Vaccination”, N. Engl. J. Med., vol. 345, No. 14, pp. 1042-1053 (2001).
Boal, et al., “Self-assembly of nanoparticles into structured spherical and network aggregates”; Nature. vol. 404, pp. 746-748 (2000).
Brown and London, “Structure of Detergent-Resistant Membrane Domains: Does Phase Separation Occur in Biological Membranes?”, Biochemical and Biophysical Research Communications, 240, pp. 1-7 (1997).
Brust, et al. , “Synthesis and Reactions of Functionalised Gold Nanoparticles”; J. Chem Soc., Chem. Commun., pp. 1655-1656 (1995).
Coteron, et al., “Glycophanes, Cyclodextrin-Cyclophane Hybrid Receptors for Apolar Binding in Aqueous Solutions. A Stereoselective Carbohydrate-Carbohydrate interation in Water”; J. Am. Chem. Soc., vol. 115, No. 22, pp. 10066-10076 (1993).
Eggens, et al., “Specific Interaction between Le′ and Le′ Determinants”, The Journal of Biological Chemistry, vol. 264, No. 16, pp. 9476-9484 (1989).
Fitzmaurice, et al., “Heterosupramolecular Chemistry: Programmed Pseudorotaxane Assembly at the Surface of a Nanocrystal”, Angew. Chem. Int. Ed. vol. 38, No. 8, pp. 1147-1150 (1999).
Frey, et al., “Role of the Glycocalyx in Regulating Access of Microparticles to Apical Plasma Membranes of Intestinal Epithelial Cells: Implications for Microbial Attachment and Oral Vaccine Targeting”, J. Exp. Med., vol. 184, pp. 1045-1059 (1996).
Hakomori, “Carbohydrate-carbohydrate interaction as an initial step in cell recognition”, Pure & Appl. Chem., vol. 63, No. 4, pp. 473-482 (1991).
Hakomori, et al., “New insights in glycosphingolipid function” ‘glycosignaling domain,’ a cell surface assembly of glycosphingolipids with signal transducer molecules, involved in cell adhesion coupled with signaling, Glycoiology, vol. 8, No. 10, pp. xi-xix (1998).
Horan, et al., “Nonstatistical binding of a protein to clustered carbohydrates”, PNAS, vol. 96, No. 21, pp. 11782-11786 (1999).
Jimenez-Barbero, et al., “Molecular Recognition of Carbohydrates using a Synthetic Receptor. A Model System to Understand the Stereo Selectivity of a Carbohydrate-Carbohydrate Interaction in Water”, J. Am. Chem. Soc., vol. 117, No. 45, pp. 11198-11204 (1995).
Kiessling and Pohl, “Strength in numbers: non-natural polyvalent carbohydrate derivatives”, Chemistry & Biology, vol. 3, No. 2, pp. 71-77 (1996).
Kitov, et al., “Shiga-like toxins are neutralized by tailored multivalent carbohydrate ligands”, Nature, vol. 403, pp. 669-672 (2000).
Klarreich, “Biologists join the dots”, Nature, vol. 413, pp. 450-452 (2001).
Liang, et al., “Polyvalent binding to carbohydrates immobilized on an insoluble resin”, Proc. Natl. Acad. Sci. USA, vol. 94, pp. 10554-10559 (1997).
Mammen, et al. “Polyvalent Interactions in Biological Systems: Implications for Design and Use of Multivalent Ligands and Inhibitors”, Angew. Chem. Int. Ed., vol. 37, pp. 2754-2794 (1998).
Misevic, “Molecular Self-Recognition and Adhesion via Proteoglycan to Proteoglycan Interations as a Pathway to Multicellularity: Atomic Force Microscopy and Color Coded Bead Measurements in Sponges”, Microscopy Research and Technique, vol. 44, pp. 304-309 (1999).
Morales, et al., “Carbohydrate-Carbohydrate Interactions in Water with Glycophanes as Model Systems”, J. Org. Chem. vol. 63, pp. 9212-9222 (1998).
Nilsson and Mandenlus, “A Carbohydrate Biosensor Surface for the Detection of Uropathogenic Bacteria”, Bio/Technology, vol. 12, pp. 1376-1378 (1994).
Revell, et al., “Self-Assembled Carbohydrate Monolayers: Formation and Surface Selective Molecular Recognition”, Langmuir, vol. 14, pp. 4517-4524 (1998).
Schmidt and Jung, “Oligosaccharide Synthesis with Trichloroacetimidates”, pp. 283-312.
Simons and Ikonen, “Functional rafts in cell membranes”, Nature, vol. 387, pp. 569-572 (1997).
Storhoff and Mirkin, “Programmed Materials Synthesis with DNA”, Chem. Rev., vol. 99, No. 7, pp. 1849-1862 (1999).
Stromberg, et al., “Saccharide orientation at the cell surface affects glycolipid receptor function”, Proc. Natl. Acad. Sci. USA, vol. 88, pp. 9340-9344 (1991).
Taton, et al., “Scanometric DNA Array Detection with Nanoparticle Probes”, Science, vol. 289, pp. 1757-1760 (2000).
Templeton, et al., “Monolayer-Protected Cluster Molecules”, Acc. Chem. Res. vol. 33, No. 1, pp. 27-36 (2000).
Templeton, et al., “Water-Soluble, Isolable Gold Clusters Protected by Tiopronin and Coenzyme A Monolayers”, Langmuir, vol. 15, pp. 66-76 (1999).
Weigel, et al., “Adhesion of Hepatocytes to Immobilized Sugars”, Journal of Biological Chemistry, vol. 254, No. 21, pp. 10830-10838 (1979).
Weis and Drickamer, “Structural basis of lectin-carbohydrate recognition”, Annu. Rev. Biochem., vol. 65, pp. 441-473 (1996).
Zutshi, et al. Inhibiting the assembly of protein-protein interfaces, Current Opinion in Chemical Biology, vol. 2, pp. 62-66 (1998).
Notice of Opposition for European Patent Application No. 05026069.4 (Feb. 25, 2011).
Hostetler, M. et al., “Alkanethiolate Gold Cluster Molecules with Core Diameters from 1.5 to 5.2nm: Core and Monolayer Properties as a Function of Core Size”, Langmuir vol. 14, pp. 17-30, 1998.
Hostetler, M. et al., “Monolayers in Three Dimensions: Synthesis and Electrochemistry of w-Functionalizes Alkanethiolate-Stabilized Gold Cluster Compounds”, Journal of American Chemistry Society, vo

Affiliated with

Also associated with

Rating

Nanoparticles does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Nanoparticles, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nanoparticles will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4304138