Nanoparticle polyanion conjugates and methods of use thereof...

Details Nanoparticle polyanion conjugates and methods of use thereof... Nanoparticle polyanion conjugates and methods of use thereof...

2007-08-07

2007-08-07

Riley, Jezia (Department: 1637)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S023100, C530S300000, C435S004000, C435S005000, C435S006120, C977S702000

Reexamination Certificate

active

10612422

ABSTRACT:
This invention provides polyanionic polymer conjugates containing non-nucleotide polyanionic polymers that are useful in detecting target analytes such as proteins or small molecules. The invention also provides nanoparticles bound to polyanionic polymer conjugates and methods of preparation and use thereof. The polyanionic polymer conjugates have the formula:in-line-formulae description="In-line Formulae" end="lead"?L-O—[PO2—O-Z-O]n—PO2—O—Xin-line-formulae description="In-line Formulae" end="tail"?wherein n ranges from 1 to 200; L represents a moiety comprising a functional group for attaching the polyanion polymer to the nanoparticle surface; Z represents a bridging group, and X represents Q, X′ or -Q-X′, wherein Q represents a functional group for attaching a recognition probe to the polyanion polymer, and X′ represents a recognition probe.

REFERENCES:
patent: 4193983 (1980-03-01), Ullman et al.
patent: 4256834 (1981-03-01), Zuk et al.
patent: 4261968 (1981-04-01), Ullman et al.
patent: 4313734 (1982-02-01), Leuvering
patent: 4318707 (1982-03-01), Litman et al.
patent: 4650770 (1987-03-01), Liu et al.
patent: 4713348 (1987-12-01), Ullman
patent: 4853335 (1989-08-01), Olsen et al.
patent: 4868104 (1989-09-01), Kurn et al.
patent: 4996143 (1991-02-01), Heller et al.
patent: 5225064 (1993-07-01), Henkens et al.
patent: 5284748 (1994-02-01), Mroczkowski et al.
patent: 5288609 (1994-02-01), Engelhardt et al.
patent: 5294369 (1994-03-01), Shigekawa et al.
patent: 5360895 (1994-11-01), Hainfeld et al.
patent: 5384073 (1995-01-01), Shigekawa et al.
patent: 5384265 (1995-01-01), Kidwell et al.
patent: 5460831 (1995-10-01), Kossovsky et al.
patent: 5472881 (1995-12-01), Beebe et al.
patent: 5508164 (1996-04-01), Kausch et al.
patent: 5514602 (1996-05-01), Brooks, Jr. et al.
patent: 5521289 (1996-05-01), Hainfeld et al.
patent: 5543158 (1996-08-01), Gref et al.
patent: 5571726 (1996-11-01), Brooks, Jr. et al.
patent: 5599668 (1997-02-01), Stimpson et al.
patent: 5609907 (1997-03-01), Natan
patent: 5637508 (1997-06-01), Kidwell et al.
patent: 5665582 (1997-09-01), Kausch et al.
patent: 5681943 (1997-10-01), Letsinger et al.
patent: 5751018 (1998-05-01), Alivisatos et al.
patent: 5830986 (1998-11-01), Merrill et al.
patent: 5900481 (1999-05-01), Lough et al.
patent: 5922537 (1999-07-01), Ewart et al.
patent: 5939021 (1999-08-01), Hansen et al.
patent: 5972615 (1999-10-01), An et al.
patent: 5990479 (1999-11-01), Weiss et al.
patent: 6025202 (2000-02-01), Natan
patent: 6149868 (2000-11-01), Natan et al.
patent: 6203989 (2001-03-01), Goldberg et al.
patent: 6214560 (2001-04-01), Yguerabide et al.
patent: 6251303 (2001-06-01), Bawendi et al.
patent: 6264825 (2001-07-01), Blackburn et al.
patent: 6277489 (2001-08-01), Abbott et al.
patent: 6306610 (2001-10-01), Bawendi et al.
patent: 6361944 (2002-03-01), Mirkin et al.
patent: 6365418 (2002-04-01), Wagner et al.
patent: 6417340 (2002-07-01), Mirkin et al.
patent: 6495324 (2002-12-01), Mirkin et al.
patent: 6506564 (2003-01-01), Mirkin et al.
patent: 6582921 (2003-06-01), Mirkin et al.
patent: 6602669 (2003-08-01), Letsinger et al.
patent: 6610491 (2003-08-01), Mirkin et al.
patent: 6645721 (2003-11-01), Mirkin et al.
patent: 6673548 (2004-01-01), Mirkin et al.
patent: 6677122 (2004-01-01), Mirkin et al.
patent: 6682895 (2004-01-01), Mirkin et al.
patent: 6709825 (2004-03-01), Mirkin et al.
patent: 6720147 (2004-04-01), Mirkin et al.
patent: 6720411 (2004-04-01), Mirkin et al.
patent: 6726847 (2004-04-01), Mirkin et al.
patent: 6730269 (2004-05-01), Mirkin et al.
patent: 6740491 (2004-05-01), Mirkin et al.
patent: 6750016 (2004-06-01), Mirkin et al.
patent: 6759199 (2004-07-01), Mirkin et al.
patent: 6767702 (2004-07-01), Mirkin et al.
patent: 6773884 (2004-08-01), Mirkin et al.
patent: 6777186 (2004-08-01), Mirkin et al.
patent: 2002/0137070 (2002-09-01), Mirkin et al.
patent: 2002/0155461 (2002-10-01), Mirkin et al.
patent: 2002/0160381 (2002-10-01), Mirkin et al.
patent: 2002/0177143 (2002-11-01), Mirkin et al.
patent: 2002/0192687 (2002-12-01), Mirkin et al.
patent: 2003/0054358 (2003-03-01), Mirkin et al.
patent: 2003/0068622 (2003-04-01), Mirkin et al.
patent: 2003/0068638 (2003-04-01), Mirkin et al.
patent: 2003/0087242 (2003-05-01), Mirkin et al.
patent: 2003/0113740 (2003-06-01), Mirkin et al.
patent: 2003/0124528 (2003-07-01), Mirkin et al.
patent: 2003/0129608 (2003-07-01), Mirkin et al.
patent: 2003/0143538 (2003-07-01), Mirkin et al.
patent: 2003/0143598 (2003-07-01), Mirkin et al.
patent: 2003/0148282 (2003-08-01), Mirkin et al.
patent: 2003/0207296 (2003-11-01), Mirkin et al.
patent: 2003/0211488 (2003-11-01), Mirkin et al.
patent: 2004/0038255 (2004-02-01), Mirkin et al.
patent: 2004/0053222 (2004-03-01), Mirkin et al.
patent: 2004/0072231 (2004-04-01), Mirkin et al.
patent: 2004/0086897 (2004-05-01), Mirkin et al.
patent: 2004/0101889 (2004-05-01), Mirkin et al.
patent: 0 630 974 (1994-06-01), None
patent: 0 667 398 (1995-08-01), None
patent: WO 89/06801 (1989-07-01), None
patent: WO 90/02205 (1990-03-01), None
patent: WO 92/04469 (1992-03-01), None
patent: WO 92/04469 (1992-05-01), None
patent: WO 93/10564 (1993-05-01), None
patent: WO 93/25709 (1993-12-01), None
patent: WO 94/29484 (1994-12-01), None
patent: WO 99/23258 (1994-12-01), None
patent: WO 97/40181 (1997-10-01), None
patent: WO 98/04740 (1998-02-01), None
patent: WO 98/04740 (1998-02-01), None
patent: WO 98/10289 (1998-03-01), None
patent: WO 98/17317 (1998-04-01), None
patent: WO 98/21587 (1998-05-01), None
patent: WO 99/20789 (1999-04-01), None
patent: WO 99/21934 (1999-05-01), None
patent: WO 99/23258 (1999-05-01), None
patent: WO 90/54509 (1999-10-01), None
patent: WO 99/60169 (1999-11-01), None
patent: WO 00/25136 (2000-05-01), None
patent: WO 00/33079 (2000-06-01), None
patent: WO 01/00876 (2001-01-01), None
patent: WO 01/00876 (2001-01-01), None
patent: WO 01/51665 (2001-07-01), None
patent: WO 01/051665 (2001-07-01), None
patent: WO 01/73123 (2001-10-01), None
patent: WO 01/073123 (2001-10-01), None
patent: WO 01/86301 (2001-11-01), None
patent: WO 01/86301 (2001-11-01), None
patent: WO 02/04681 (2002-01-01), None
patent: WO 02/004681 (2002-01-01), None
patent: WO 02/18643 (2002-03-01), None
patent: WO 02/018643 (2002-03-01), None
patent: WO 02/36169 (2002-05-01), None
patent: WO 00/33079 (2002-06-01), None
patent: WO 02/46472 (2002-06-01), None
patent: WO 02/046472 (2002-06-01), None
patent: WO 02/46483 (2002-06-01), None
patent: WO 02/079490 (2002-10-01), None
patent: WO 02/096262 (2002-12-01), None
patent: WO 03/008539 (2003-01-01), None
patent: WO 03/035829 (2003-05-01), None
patent: WO 03/081202 (2003-10-01), None
patent: WO 03/087188 (2003-10-01), None
patent: WO 03/095973 (2003-11-01), None
patent: WO 2004/004647 (2004-01-01), None
patent: WO 2004/053105 (2004-06-01), None
Otsuka, Hidenori, et al, “Quantitative and Reversible Lectin-Induced Association of Gold Nanoparticles Modified with a-Lactosyl-w-mercapto-poly(ethylene glycol,)”Journal of the American Chemical Society, vol. 123, p. 8226-8230 (2001).
Ahmadi, T.S. et al.,Science,272, 1924 (1996).
Bahnemann, inPhotochemical Conversion and Storage of Solar Energy(eds. Pelizetti and Schiavello 1991), p. 251.
Bassell, et al.,J. Cell Biol.,126, 863-876 (1994).
Bottomley et al., J. Vac. Sci. Technol. A, 10, 591 (1992).
Braun et al.,Nature,391, 775 (1998).
Braun-Howland et al.,Biotechniques,13, 928-931 (1992).
Brousseau et al., J. Am. Chem. Soc., 120: 7645 (1998).
Brus,Appl. Phys. A.,53, 465 (1991).
Burwell,Chemical Technology,4, 370-377 (1974).
Chrisey et al., Nucleic Acids Res., 24, 3031-3039 (1996).
Chrisey et al., Nucleic Acids Res., 24, 3040-3047 (1996).
Curtis, A.C., et al.,Angew. Chem. Int. Ed. Engl.,27, 1530 (1988).
Elghanian et al., Science, 277: 1078 (1997).
Freeman et al., Science, 267: 1629 (1995).
D. I. Gittins, F. Caruso,J. Phys. Chem. B105, 6846-6852 (2001).
Grabar et al.,Anal. Chem.,67, 735-743 (1995).
Hegner et al., FEBS Lett., 336, 452 (1993).
Henglein,Chem. Rev.,89, 1861 (1989).
Henglein, A. et al.,J. Phys. Chem.,9

Affiliated with

Also associated with

Rating

Nanoparticle polyanion conjugates and methods of use thereof... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Nanoparticle polyanion conjugates and methods of use thereof..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nanoparticle polyanion conjugates and methods of use thereof... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3839220