Nanoparticle imaging system and method

Details Nanoparticle imaging system and method Nanoparticle imaging system and method

2006-09-19

2006-09-19

Wu, Jingge (Department: 2624)

Image analysis

Applications

Biomedical applications

C382S129000, C382S130000, C382S133000, C382S134000

Reexamination Certificate

active

07110585

ABSTRACT:
An apparatus and method for imaging metallic nanoparticles is provided. Preferably, the invention provides for an apparatus and method for detection of gold colloid particles and for accurate reporting to the operator. The apparatus includes a substrate holder for holding the substrate, a processor and memory device, an imaging module, an illumination module, a power module, an input module, and an output module. The apparatus may have a stationary substrate holder and imaging module which are proximate to one another. The apparatus provided for a compact sized system without the need for complex motorized devices to move the camera across the substrate. Further, the apparatus and method provide for automatic detection of the spots/wells on the substrate, automatic quantification of the spots on the substrate, and automatic interpretation of the spots based on decision statistics.

REFERENCES:
patent: 4202037 (1980-05-01), Glaser et al.
patent: 5018219 (1991-05-01), Matsuzaki et al.
patent: 5428690 (1995-06-01), Bacus et al.
patent: 5599668 (1997-02-01), Stimpson et al.
patent: 6143247 (2000-11-01), Sheppard, Jr. et al.
patent: 6212292 (2001-04-01), Soares
patent: 6214560 (2001-04-01), Yguerabide et al.
patent: 6248988 (2001-06-01), Krantz
patent: 6268218 (2001-07-01), Pantoliano et al.
patent: 6286763 (2001-09-01), Reynolds et al.
patent: 6396941 (2002-05-01), Bacus et al.
patent: 6649403 (2003-11-01), McDevitt et al.
patent: 6728417 (2004-04-01), Hara et al.
patent: 2003/0095764 (2003-05-01), Pering et al.
patent: 2003/0224505 (2003-12-01), Patno et al.
patent: 2004/0014106 (2004-01-01), Patno et al.
patent: WO 98/44330 (1998-10-01), None
patent: WO 99/13319 (1999-03-01), None
patent: WO 02/086468 (2002-10-01), None
patent: WO 03/053535 (2003-07-01), None
patent: WO 03/060446 (2003-07-01), None
Sonnichsen, C. et al., “Spectroscopy of single metallic nanoparticles using total internal reflection microscopy”,Applied Physics Letters, vol. 77, No. 19, 2000, pp. 2949-2951.
Storhoff, J. et al., “Homogeneous detection of unamplified genomic DNA sequences based on colorimetric scatter of gold nanoparticle probes”,Nature Biotechnology, vol. 22, No. 7, 2004, pp. 883-887.
Storhoff, J. et al., “Gold nanoparticle-based detection of genomic DNA targets on microarrays using a novel optical detection system”,Biosensors&Bioelectronics, vol. 19, 2004, pp. 875-883.
Taton, T. et al., “Scanometric DNA Array Detection with Nanoparticle Probes”,Science, vol. 289, 2000, pp. 1757-1760.
Alexandre, I. et al., “Colorimetric Silver Detection of DNA Microarrays”,Analytical Biochemistry, vol. 295, No. 1, 2001, pp. 1-8.
Brown, C.S., et al., “Image metrics in the statistical analysis of DNA microarray data,” Proceedings of the National Academy of Sciences of USA, National Academy of Science, Washington D.C., US, vol. 98, No. 16, Jul. 31, 2001, pp. 8944-8949.
Takahagi, T., et al., “Scanning Electron Microscope Observation of Heterogeneous Three-Dimensional Nanoparticle Arrays Using DNA,” Japanese Journal of Applied Physics, Japan Society of Applied Physics, Tokyo, Japan, vol. 40, No. 5B, Part 2, May 15, 2001, pp. L521-L523.

Affiliated with

Also associated with

Rating

Nanoparticle imaging system and method does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Nanoparticle imaging system and method, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nanoparticle imaging system and method will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3603764