Nanoparticle formulations of platinum compounds

Details Nanoparticle formulations of platinum compounds Nanoparticle formulations of platinum compounds

2005-03-24

2009-11-03

Gonzalez, Porfirio Nazario (Department: 1621)

Drug, bio-affecting and body treating compositions

Inorganic active ingredient containing

Heavy metal or compound thereof

C556S137000, C514S492000, C977S717000, C977S911000

Reexamination Certificate

active

07611733

ABSTRACT:
Solid Lipid Nanoparticles of platinum compounds, particularly of antitumor platinum complexes are disclosed. The Nanoparticles of the invention are obtained by a process comprising: a) preparing a first microemulsion by mixing a molten lipid, a surfactant, and optionally a co-surfactant and the platinum compound acqueous solution; b) preparing a solution by mixing a surfactant and optionally a co-surfactant in water, heating to complete solution, preferably at the same melting temperature of the lipid used in a) and adding a co-surfactant; c) dispersing the microemulsion obtained in a) into the solution obtained in b) obtaining a multiple microemulsion c); d) dispersing the microemulsion obtained in c) in aqueous medium at a temperature ranging from 0.5° C. to 4° C. obtaining a dispersion of solid lipid microspheres; e) washing with aqueous medium through ultrafiltration the obtained lipid microspheres obtained in d) and lyophilizing, optionally in the presence of a bulking agent and of a cryoprotecting agent.

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patent: WO-94/20072 (1994-09-01), None
patent: WO-93/05768 (1996-04-01), None
Egea et al., “Penetration kinetics of cis-diamminedichloroplatinum(II) loaded nanoparticles in lipid monolayers as a membrane model of the reticuloendothelial system”, Thin Solid Films, vol. 210/211, pp. 364-367, 1992.

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