Nanofibrous biocomposite prosthetic vascular graft

Prosthesis (i.e. – artificial body members) – parts thereof – or ai – Arterial prosthesis – Made of synthetic material

Reexamination Certificate

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Details

C264S465000

Reexamination Certificate

active

07413575

ABSTRACT:
The present invention provides a bioactive, small-diameter (typically less than 6 mm in internal diameter) vascular graft prosthesis, and is a textile conduit preferably manufactured using a novel electrospinning perfusion methodology. One preferred embodiment is a nanofibrous biocomposite textile conduit which comprises a prepared liquid admixture of polyester (Dacron), a biodurable implantable synthetic polymer, and Type IV collagen, an extracellular matrix protein. This prepared admixture and blending of diverse fibrous matter is utilized in a novel electrospinning perfusion process to form a small-diameter (less than 6 mm) fabricated textile conduit, a discrete article of manufacture, which then serves as an antecedent tangible workpiece for a subsequently-made prosthetic vascular graft construct.

REFERENCES:
patent: 6626939 (2003-09-01), Burnside et al.
patent: 6713011 (2004-03-01), Chu et al.
patent: 7056339 (2006-06-01), Elkins et al.
patent: 2002/0090725 (2002-07-01), Simpson et al.
patent: 2003/0215624 (2003-11-01), Layman et al.
patent: 2004/0199241 (2004-10-01), Gravett et al.

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