Nanoerythrosome as bioactive agent carrier

Details Nanoerythrosome as bioactive agent carrier Nanoerythrosome as bioactive agent carrier

1996-07-15

1997-08-05

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

A61K 9127

Patent

active

056539991

ABSTRACT:
Carriers for pharmacologic agents comprise nanoerythrosomes, which are vesicles prepared by the extrusion of red blood cell ghosts, the average diameter of these vesicles is 0.1 .mu.m; the daunorubicin was covalently linked to nanoerythrosomes and the cytotoxicity of daunorubicin conjugated to nanoerythrosomes was assessed on P388D.sub.1 cell line; the results indicated that the cytotoxicity of conjugated daunorubicin was higher than the free daunorubicin, similar results were observed on CDF.sub.1 mice bearing grafted P388D.sub.1 leukemia tumors; daunorubicin-nanoerythrosome conjugates had a higher antineoplastic activity than the free bioactive agent.

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