Nanocrystalline magnetic iron oxide particles-method for prepara

Details Nanocrystalline magnetic iron oxide particles-method for prepara Nanocrystalline magnetic iron oxide particles-method for prepara

1992-05-13

1995-06-27

Hollinden, Gary E.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

436173, 514 54, 514 56, 1286534, 424 9322, A61B 5055

Patent

active

054277671

ABSTRACT:
The invention relates to nanocrystalline magnetic particles consisting of gnetic iron oxide core of Fe.sub.3 O.sub.4, gamma-Fe.sub.2 O.sub.3 or mixtures thereof and an envelope chemisorbed to said core, the method for preparation of these particles as well as the use thereof in medical diagnostics and/or therapy. The magnetic particles, according to the invention, are characterized by composition of the coating material of natural or synthetic glycosaminoglycans and/or their derivatives with molecular weights of 500 Da to 250,000 Da, if necessary, covalently cross-linked with appropriate cross-linking agents and/or modified by specific additives.

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