Nanocochleate formulations, process of preparation and method of

Details Nanocochleate formulations, process of preparation and method of Nanocochleate formulations, process of preparation and method of

1999-01-22

2000-11-28

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

424400, 424427, 424430, 424434, 424435, 424436, 436829, 514966, 514967, A61K 9127, A61K 900

Patent

active

061532177

ABSTRACT:
A process for producing a small-sized, lipid-based cochleate is described. Cochleates are derived from liposomes which are suspended in an aqueous two-phase polymer solution, enabling the differential partitioning of polar molecule based-structure by phase separation. The liposome-containing two-phase polymer solution, treated with positively charged molecules such as Ca.sup.2+ or Zn.sup.2+, forms a cochleate precipitate of a particle size less than one micron. The process may be used to produce cochleates containing pharmaceutical agents or biologically relevant molecules. Small-sized cochleates may be administered orally or through the mucosa to obtain an effective method of treatment.

REFERENCES:
patent: 4871488 (1989-10-01), Mannino
patent: 4990291 (1991-02-01), Schoen
patent: 5269979 (1993-12-01), Fountain
patent: 5643574 (1997-07-01), Gould et al.
patent: 5994318 (1999-11-01), Gould et al.

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