Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Reexamination Certificate
2006-08-18
2009-08-04
Mosher, Mary E (Department: 1648)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
C435S041000, C435S235100, C977S802000
Reexamination Certificate
active
07569340
ABSTRACT:
A nanoarray template utilizing coordination chemistry or metal ion binding to control the site-isolation and orientation of virus particles is provided. The nanoarray template is generated by lithography including Dip Pen Nanolithography. The surface chemistry that is inherent in many viruses, metal-ion based or inorganic coordination chemistry is used to immobilize individual virus particles without the need for their genetic modification. Single particle control enables a wide variety of studies involving viruses that are not possible with microarrays, including single particle, single cell infectivity studies, exploration of such structures as templates in materials synthesis and molecular electronics, and studies aimed at understanding how surface presentation influences their bioactivity. This is an example of such control at the single-particle level, and therefore, commercial use of nanoarrays in biological systems.
REFERENCES:
patent: 6635311 (2003-10-01), Mirkin et al.
patent: 6827979 (2004-12-01), Mirkin et al.
patent: 6887443 (2005-05-01), Liu et al.
patent: 2003/0068446 (2003-04-01), Mirkin et al.
patent: WO 2006/138272 (2006-12-01), None
Chueng, et al. Fabrication of Assembled Virus Nanostructures on Templates of Chemoselective Linkers Fromed by Scanning Probe Nanolithography. J Am Chem Soc. 2003; 125:6848-6849.
U.S. Appl. No. 60/689,828, filed Jun. 13, 2005, Mirkin et al.
Advanced Inorganic Chemistry, 4THEd., Coon and Wilkinson (1980).
Basu, G., et al., “Metal binding to cowpea chlorotic mottle virus using terbium(III fluorescence”J. Biol. Inorg. Chem., vol. 8, 721-725 (2003).
Bohinski, R. C., Modern Concepts in BioChemistry, 4thEd. (1983).
Cann, A.J.,Principles of Modern Virology, Academic Press (1993).
Cheung, C. L., et al., “Fabrication of Assembled Virus Nanostructures on Templates of Chemoselective Linkers Formed by Scanning Probe Nanolithography”J. Am. Chem. Soc., vol. 125, 6848-6849 (2003).
Chiu, W., Burnett, R.M., and Garcea, R.L. (Eds),StructuralBiology of Viruses, Oxford University Press (1997).
Demers, L. M., et al., “Direct Patterning of Modified Oligonucleotides on Metals and Insulators by Dip-Pen Nanolithography”,Science, vol. 296, 1836-1838 (2002).
Direct-Write Technologies for Rapid Prototyping Applications (Ed. Alberto Pique and D.B. Chrisey), Academic (2002).
Dujardin, E., et al., “Organization of Metallic Nanoparticles Using Tobacco Mosaic Virus Templates”, Nano Lett., vol. 3, 413-417 (2003).
Fraser, R. D. B., Infra-Red Dichroism of Tobacco Mosaic Virus Nucleoprotein,Nature, vol. 29, 491 (1952).
Frey, B. L., et al., “Covalent Attachment and Derivatization of Poly(L-lysine) Monolayers on Gold Surfaces As Characterized by Polarization-Modulation FT-IR Spectroscopy”,Anal. Chem., vol. 68, 3187-3193 (1996).
G. MacBeath, Printing Proteins as Microarrays for High-Throughput Function Determination,Science, vol. 289, pp. 1760-1763 (2000).
Ginger, D. S., “The Evolution of Dip-Pen Nanolithography”,Angew Chem. Int. Ed., 43, 30-45 (2004).
Guthold, M., et al., “Investigation and modification of molecular structures with the nanoManipulator”,J. Mol. Graphics Mod., vol. 17, 187-197 (1999).
Heller, R. A., “Discovery and analysis of inflammatory disease-related genes using cDNA microarrays”,Proc. Natl. Acad. Sci. USA, vol. 94, pp. 2150-2155 (1997).
Hyun, J., et al., “Capture and Release of Proteins on the Nanoscale by Stimuli-Responsive Elastin-Like Polypeptide ‘Switches’”,J. Am. Chem. Soc., vol. 126, 7330-7335 (2004).
King, L., et al., “Derivatisation of Carboxyl Groups of Tobacco Mosaic Virus with Cystamine”,Biochim. Biophys. Acta, vol. 322, 279-293 (1973).
Knez, M., et al., “Binding the Tobacco Mosaic Virus to Inorganic Surfaces”,Langmuir, vol. 20, 441-447 (2004).
Knez, M., et al., “Biotemplate Synthesis of 3-nm Nickel and Cobalt Nanowires”,Nano Lett., vol. 3, 1079-1082 (2003).
Lee, K.-B., et al., “Protein Nanoarrays Generated By Dip-Pen Nanolithography”,Science, vol. 295, 1702-1705 (2002).
Lindroos, K., “Multiplex SNP genotyping in pooled DNA samples by a four-colour microarray system”,Nucleic Acid Res.,vol. 30, pp. e70-e78 (2002).
Maeda, H., “An Atomic Force Microscopy Study for the Assembly Structures of Tobacco Mosaic Virus and Their Size Evaluation”,Langmuir, vol. 13, 4150-4161 (1997).
Miller, U. R.,Microarray Technology and Its Applications, Springer, New York (2005).
Schena, M., “Quantitative Monitoring of Gene Expression Patterns with a Complementary DNA Microarray”,Science, vol. 270, pp. 467-470 (1995).
Shenton, W., et al., “Inorganic-Organic Nanotube Composites from Template Mineralization of Tobacco Mosaic Virus”,Adv. Mater., vol. 11, 253-256 (1999).
Smith, J. C., “Nanopatterning the Chemospecific Immobilization of Cowpea Mosaic Virus Capsid”,Nano Lett., vol. 3, 883-886 (2003).
Vega, R. A., “Nanoarrays of Single Virus Particles”, Chem. Int. Ed., vol. 44, No. 2-4, pp. 6013-6015 (2005).
Wilson, T. M. A., “Modification of the Coat Protein Charge and Its Effect on the Stability of the U1Strain of Tobacco Mosaic Virus as Alkaline pH”,Virology, vol. 140, 21-27 (1985).
Rozhok, S. et al., “Methods for fabricating microarrays of motile bacteria,” Small (Weinheim an der Bergstrasse, Germany), vol. 1, No. 4, pp. 445-451, XP002470255, ISSN: 1613-6829 (2005).
Salaita, K., et al., “Sub-100 nm, centimeter-scale, paraleel dip-pen nanolithography,” Small (Weinheim an der Bergstrasse, Germany), vol. 1, No. 10, pp. 940-945, XP002470257, ISSN: 1613-6829 (2005).
Vega, R. A., et al., “Functional antibody arrays through metal ion-affinity templates,” Chemobiochem, vol. 7, No. 11, pp. 1653-1657, 1632, XP002470256, ISSN: 1439-4227 (2006).
Search Report, PCT/US2006/032316, dated Mar. 6, 2008 (2 pages).
Maspoch Daniel
Mirkin Chad A.
Salaita Khalid
Vega Rafael A.
Foley & Lardner LLP
Mosher Mary E
Northwestern University
Snyder Stuart W
LandOfFree
Nanoarrays of single virus particles, methods and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Nanoarrays of single virus particles, methods and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nanoarrays of single virus particles, methods and... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4055264