Nano-scaled dendrimer-based colorimetric biosensors

Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals – Carrier is organic

Reexamination Certificate

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C435S006120, C436S164000, C436S172000, C436S531000, C436S546000, C436S805000, C436S501000

Reexamination Certificate

active

07045367

ABSTRACT:
Molecular chemical and/or biological sensors that exhibit a very high density of sensing functionality and which are applicable to a wide variety of different analytes, and enable rapid, convenient and economical detection of analytes are prepared by reacting a dendritic polymer with a diacetylene reagent wherein the diacetylene functional groups are subsequently intramolecularly polymerized to form segments having alternating conjugated double and triple bonds. Sensory groups that can bind with an analyte are bonded to the acetylene monomer units to form molecular sensors that produce observable and measurable color changes when an analyte binds with the sensory groups.

REFERENCES:
patent: 5622872 (1997-04-01), Ribi
patent: 6001556 (1999-12-01), Charych et al.
patent: 6022748 (2000-02-01), Charych et al.
Sui, G., Micic, M., Huo, Q., Leblanc, R. M.; “Studies of a Novel Polymerizable Amphiphilic Dendrimer”Colloids and Surfaces A: Physicochemical and Engineering Aspects, 171 (2000) pp. 185-197.
Balogh L. et al., “Architectural Copolymers of PAMSAM Dendrimers and Ionic Polyacetylenes,”Macromolecules, vol. 32, No. 4, Feb. 23, 1999, pp. 1036-1042.

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